HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis

Yanjiao Ding, Zhenyu Li, Yaoyao Li, Chunhua Lu, Haoxin Wang, Yuemao Shen, Liangcheng Du

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Heat-stable antifungal factor (HSAF) belongs to polycyclic tetramate macrolactams (PTMs), which inhibits many fungal pathogens and is effective in inhibiting Candida albicans (C. albicans). In this study, we found that HSAF induced the apoptosis of C. albicans SC5314 through inducing the production of reactive oxygen species (ROS). Nevertheless, we validated the efficacy of HSAF against candidiasis caused by C. albicans in a murine model in vivo, and HSAF significantly improved survival and reduced fungal burden compared to vehicles. A molecular dynamics (MD) simulation was also investigated, revealing the theoretical binding mode of HSAF to the β-tubulin of C. albicans. This study first found PTMs-induced fungal apoptosis through ROS accumulation in C. albicans and its potential as a novel agent for fungicides.

Original languageEnglish (US)
Pages (from-to)30895-30904
Number of pages10
JournalRSC Advances
Volume6
Issue number37
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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