HSPA5 is an essential host factor for Ebola virus infection

St Patrick Reid, Amy C. Shurtleff, Julie A. Costantino, Sarah R. Tritsch, Cary Retterer, Kevin B. Spurgers, Sina Bavari

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Development of novel strategies targeting the highly virulent ebolaviruses is urgently required. A proteomic study identified the ER chaperone HSPA5 as an ebolavirus-associated host protein. Here, we show using the HSPA5 inhibitor (-)- epigallocatechin gallate (EGCG) that the chaperone is essential for virus infection, thereby demonstrating a functional significance for the association. Furthermore, in vitro and in vivo gene targeting impaired viral replication and protected animals in a lethal infection model. These findings demonstrate that HSPA5 is vital for replication and can serve as a viable target for the design of host-based countermeasures.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalAntiviral Research
Volume109
Issue number1
DOIs
StatePublished - Sep 2014
Externally publishedYes

Keywords

  • Antiviral
  • Ebolavirus
  • HSPA5

ASJC Scopus subject areas

  • Pharmacology
  • Virology

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