Human ESC/iPSC-based 'omics' and bioinformatics for translational research

Gerd A. Müller, Kirill V. Tarasov, Rebekah L. Gundry, Kenneth R. Boheler

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

The establishment of human embryonic stem cell lines (hESCs) created the basis for new approaches in regenerative medicine and drug discovery. Despite the potential of hESCs for cell-based therapies, ethical controversies limit their use. These obstacles could be overcome by induced pluripotent stem cells (iPSCs) that are generated by reprogramming somatic cells. Before iPSCs can be used for clinical applications, however, they must be thoroughly analyzed for aberrations in the genome, epigenome, transcriptome and proteome. Here, we review how 'omics' technologies can be employed for a quantitative and definitive assessment of these cells.

Original languageEnglish (US)
Pages (from-to)e161-e170
JournalDrug Discovery Today: Disease Models
Volume9
Issue number4
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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