Human growth hormone but not human insulin-like growth factor-I enhances recovery from neonatal malnutrition in rats

X. Zhao, T. G. Unterman, S. M. Donovan

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The ability of hormonal therapy to enhance recovery from neonatal malnutrition was assessed in rats. Pups were malnourished via maternal food restriction (60% control intake). On d 16, restricted pups (n = 50) (62% control body wt) were refed until d 20 and were given growth hormone, insulin-like growth factor-I, destripeptide [1,3] insulin-like growth factor- I, or saline (placebo). Refed-placebo pups attained 80% of control body weight by d 20. Growth hormone treatment caused a greater weight gain than refeeding alone (P ≤ 0.05). Treatment with insulin-like growth factor-I and destripeptide [1,3] insulin-like growth factor-I did not affect body weight. All three hormones increased spleen and kidney weights (P ≤ 0.05) compared with the refed-placebo group, whereas only growth hormone increased muscle weight (P ≤ 0.05). Malnourished pups had lower serum insulin-like growth factor-I (P ≤ 0.05) and insulin-like growth factor binding protein-3 (P ≤ 0.05), and higher serum insulin-like growth factor binding protein-2 (P ≤ 0.05) and hepatic insulin-like growth factor binding protein-2 mRNA (P ≤ 0.05) than controls. Refeeding increased serum insulin-like growth factor-I compared with restricted pups (P ≤ 0.05), and insulin-like growth factor-I treatment caused a further increase in serum insulin-like growth factor-I compared with the refed-placebo group (P ≤ 0.05). These results show that growth hormone was moderately effective at increasing body weight gain and muscle growth during recovery from malnutrition.

Original languageEnglish (US)
Pages (from-to)1316-1327
Number of pages12
JournalJournal of Nutrition
Volume125
Issue number5
StatePublished - 1995

Keywords

  • growth hormone
  • insulin-like growth factor
  • protein-energy malnutrition
  • rats

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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