TY - JOUR
T1 - Human herpesvirus 8 as a potential sexually transmitted agent in honduras
AU - Sosa, C.
AU - Klaskala, W.
AU - Chandran, B.
AU - Soto, R.
AU - Sieczkowski, L.
AU - Wu, M. H.
AU - Baum, M.
AU - Wood, C.
N1 - Funding Information:
Financial support: PHS grant 30356 (to C.W. and B.C.); Nebraska Health Foundation grant (to C.W.). C. Sosa is a scholar in the AIDS International Training and Research Program at the University of Miami School of Medicine, sponsored by the Fogarty International Center, NIH (D-43-T-W-0017-09).
PY - 1998
Y1 - 1998
N2 - The seroprevalence of human herpesvirus 8 (HHV-8) was studied in 326 human immunodeficiency virus (HIV)-positive and -negative persons from Honduras; women constituted 77% (n = 251) of the subjects. Sera were tested for lytic HHV-8 antibodies by an IFA, and positive samples were confirmed by a radioimmunoprecipitation assay. Of the 326 persons tested, 58 (17.8%) had HHV-8 antibodies. Among the HIV-infected women, 22.7% were seropositive; 11.3% of the HIV-negative women were seropositive. HHV-8 seroprevalence was almost four times higher in HIV-positive female commercial sex workers (36%) than in HIV-negative female non-commercial sex workers (9.9%; odds ratio = 3.8, 95% confidence interval = 1.1-13; P = 0.01), suggesting that commercial sex work is a risk factor for HHV-8 infection. In the men studied, the overall HHV-8 seroprevalence was 22.6%, with a seropositivity rate of 28% for HIV-positive men compared with 12% for HIV-negative men.
AB - The seroprevalence of human herpesvirus 8 (HHV-8) was studied in 326 human immunodeficiency virus (HIV)-positive and -negative persons from Honduras; women constituted 77% (n = 251) of the subjects. Sera were tested for lytic HHV-8 antibodies by an IFA, and positive samples were confirmed by a radioimmunoprecipitation assay. Of the 326 persons tested, 58 (17.8%) had HHV-8 antibodies. Among the HIV-infected women, 22.7% were seropositive; 11.3% of the HIV-negative women were seropositive. HHV-8 seroprevalence was almost four times higher in HIV-positive female commercial sex workers (36%) than in HIV-negative female non-commercial sex workers (9.9%; odds ratio = 3.8, 95% confidence interval = 1.1-13; P = 0.01), suggesting that commercial sex work is a risk factor for HHV-8 infection. In the men studied, the overall HHV-8 seroprevalence was 22.6%, with a seropositivity rate of 28% for HIV-positive men compared with 12% for HIV-negative men.
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U2 - 10.1086/517471
DO - 10.1086/517471
M3 - Article
C2 - 9697741
AN - SCOPUS:0031872392
SN - 0022-1899
VL - 178
SP - 547
EP - 551
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -