Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6

Kirsten B. Bibbins; Jen Yue Tsai; John Schimenti; Nora Sarvetnick; Huda Y. Zoghbi; Peter Goodfellow; Lee M. Silver

doi:10.1016/0888-7543(89)90098-0

Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6

Kirsten B. Bibbins, Jen Yue Tsai, John Schimenti, Nora Sarvetnick, Huda Y. Zoghbi, Peter Goodfellow, Lee M. Silver

Research output: Contribution to journal › Article › peer-review

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Abstract

Our laboratory has recently cloned and characterized two testes-expressed loci-the Tcp-10 gene family cluster and the D17Si11 gene-that map to the proximal portion of mouse chromosome 17. Human homologs of both loci have been identified and cloned. Somatic cell hybrid lines have been used to map the human homolog of D17Si11 to the short arm of chromosome 6 (p11-p21.1) along with homologs of other genes from the (Pim-1)-(Pgk-2) region of the mouse chromosome. The human TCP 10 locus maps to the long arm of chromosome 6 (q21-qter) along with homologs of other genes from the mouse chromosome 17 region between the centromere and Pim-1. The mapping of large portions of the mouse t haplotype to unlinked regions on human chromosome 6 rules out the possibility that a t-haplotype-like chromosome could exist in humans.

Original language	English (US)
Pages (from-to)	139-143
Number of pages	5
Journal	Genomics
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/0888-7543(89)90098-0
State	Published - Jul 1989
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1016/0888-7543(89)90098-0

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title = "Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6",

abstract = "Our laboratory has recently cloned and characterized two testes-expressed loci-the Tcp-10 gene family cluster and the D17Si11 gene-that map to the proximal portion of mouse chromosome 17. Human homologs of both loci have been identified and cloned. Somatic cell hybrid lines have been used to map the human homolog of D17Si11 to the short arm of chromosome 6 (p11-p21.1) along with homologs of other genes from the (Pim-1)-(Pgk-2) region of the mouse chromosome. The human TCP 10 locus maps to the long arm of chromosome 6 (q21-qter) along with homologs of other genes from the mouse chromosome 17 region between the centromere and Pim-1. The mapping of large portions of the mouse t haplotype to unlinked regions on human chromosome 6 rules out the possibility that a t-haplotype-like chromosome could exist in humans.",

author = "Bibbins, {Kirsten B.} and Tsai, {Jen Yue} and John Schimenti and Nora Sarvetnick and Zoghbi, {Huda Y.} and Peter Goodfellow and Silver, {Lee M.}",

year = "1989",

month = jul,

doi = "10.1016/0888-7543(89)90098-0",

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T1 - Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6

AU - Bibbins, Kirsten B.

AU - Tsai, Jen Yue

AU - Schimenti, John

AU - Sarvetnick, Nora

AU - Zoghbi, Huda Y.

AU - Goodfellow, Peter

AU - Silver, Lee M.

PY - 1989/7

Y1 - 1989/7

N2 - Our laboratory has recently cloned and characterized two testes-expressed loci-the Tcp-10 gene family cluster and the D17Si11 gene-that map to the proximal portion of mouse chromosome 17. Human homologs of both loci have been identified and cloned. Somatic cell hybrid lines have been used to map the human homolog of D17Si11 to the short arm of chromosome 6 (p11-p21.1) along with homologs of other genes from the (Pim-1)-(Pgk-2) region of the mouse chromosome. The human TCP 10 locus maps to the long arm of chromosome 6 (q21-qter) along with homologs of other genes from the mouse chromosome 17 region between the centromere and Pim-1. The mapping of large portions of the mouse t haplotype to unlinked regions on human chromosome 6 rules out the possibility that a t-haplotype-like chromosome could exist in humans.

AB - Our laboratory has recently cloned and characterized two testes-expressed loci-the Tcp-10 gene family cluster and the D17Si11 gene-that map to the proximal portion of mouse chromosome 17. Human homologs of both loci have been identified and cloned. Somatic cell hybrid lines have been used to map the human homolog of D17Si11 to the short arm of chromosome 6 (p11-p21.1) along with homologs of other genes from the (Pim-1)-(Pgk-2) region of the mouse chromosome. The human TCP 10 locus maps to the long arm of chromosome 6 (q21-qter) along with homologs of other genes from the mouse chromosome 17 region between the centromere and Pim-1. The mapping of large portions of the mouse t haplotype to unlinked regions on human chromosome 6 rules out the possibility that a t-haplotype-like chromosome could exist in humans.

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Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6

Abstract

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