Abstract
Hepatotropic viruses induced hepatitis progresses much faster and causes more liver- related health problems in people co-infected with human immunodeficiency virus (HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus (HBV) and hepatitis C virus (HCV) causes significant numbers of non-acquired immune deficiency syndrome (AIDS)-related deaths in coinfected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals (DAA) and antiretroviral therapy (ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV coinfected individuals.
Original language | English (US) |
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Pages (from-to) | 398-410 |
Number of pages | 13 |
Journal | World Journal of Gastroenterology |
Volume | 25 |
Issue number | 4 |
DOIs | |
State | Published - Jan 28 2019 |
Keywords
- Fibrosis
- Hepatitis B virus
- Hepatitis C virus
- Human immunodeficiency virus
- Stiffness
- Treatment
ASJC Scopus subject areas
- Gastroenterology