Human immunodeficiency virus and hepatotropic viruses comorbidities as the inducers of liver injury progression

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7 Scopus citations

Abstract

Hepatotropic viruses induced hepatitis progresses much faster and causes more liver- related health problems in people co-infected with human immunodeficiency virus (HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus (HBV) and hepatitis C virus (HCV) causes significant numbers of non-acquired immune deficiency syndrome (AIDS)-related deaths in coinfected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals (DAA) and antiretroviral therapy (ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV coinfected individuals.

Original languageEnglish (US)
Pages (from-to)398-410
Number of pages13
JournalWorld Journal of Gastroenterology
Volume25
Issue number4
DOIs
StatePublished - Jan 28 2019

Keywords

  • Fibrosis
  • Hepatitis B virus
  • Hepatitis C virus
  • Human immunodeficiency virus
  • Stiffness
  • Treatment

ASJC Scopus subject areas

  • Gastroenterology

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