Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to zidovudine and other nucleoside analog inhibitors in vitro

Robert A. Smith, Geoffrey S. Gottlieb, Donovan J. Anderson, Crystal L. Pyrak, Bradley D. Preston

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Using an indicator cell assay that directly quantifies viral replication, we show that human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2, respectively) exhibit similar sensitivities to 3′-azido-3′- deoxythymidine (zidovudine) as well as other nucleoside analog inhibitors of reverse transcriptase. These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection.

Original languageEnglish (US)
Pages (from-to)329-332
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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