TY - JOUR
T1 - Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to zidovudine and other nucleoside analog inhibitors in vitro
AU - Smith, Robert A.
AU - Gottlieb, Geoffrey S.
AU - Anderson, Donovan J.
AU - Pyrak, Crystal L.
AU - Preston, Bradley D.
PY - 2008/1
Y1 - 2008/1
N2 - Using an indicator cell assay that directly quantifies viral replication, we show that human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2, respectively) exhibit similar sensitivities to 3′-azido-3′- deoxythymidine (zidovudine) as well as other nucleoside analog inhibitors of reverse transcriptase. These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection.
AB - Using an indicator cell assay that directly quantifies viral replication, we show that human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2, respectively) exhibit similar sensitivities to 3′-azido-3′- deoxythymidine (zidovudine) as well as other nucleoside analog inhibitors of reverse transcriptase. These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection.
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U2 - 10.1128/AAC.01004-07
DO - 10.1128/AAC.01004-07
M3 - Article
C2 - 17967913
AN - SCOPUS:37849043631
SN - 0066-4804
VL - 52
SP - 329
EP - 332
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 1
ER -