Human lymphocyte biology and its application to humanized mice

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter describes lymphocyte maturation and differentiation. Interactions of lymphoid tissues with the central and peripheral nervous systems play a fundamental role in health and disease. Recent advances in xenobiology has opened new approaches to study relationships between peripheral immunity and nervous system development, homeostasis, response to injuries, and disease in animal models. Humanized animal models help to study the complexity of human immune system development and adaptive immune responses. Humanization of a mouse brain with human glial cells provides an additional tool to study hemato-lymphoid brain interactions in small animals.

Original languageEnglish (US)
Title of host publicationNeuroimmune Pharmacology
PublisherSpringer International Publishing
Pages201-216
Number of pages16
ISBN (Electronic)9783319440224
ISBN (Print)9783319440200
DOIs
StatePublished - Jan 1 2016

Keywords

  • Antibodies
  • B cells
  • Effector memory T cells
  • Follicular dendritic cells (FDCs)
  • Immune priledged
  • Regulatory T cells
  • Stat4
  • Stat6
  • T-Bet

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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