Human lymphocyte biology and its application to humanized mice

Larisa Y. Poluektova

doi:10.1007/978-3-319-44022-4_14

Human lymphocyte biology and its application to humanized mice

Larisa Y. Poluektova

Pharmacology & Experimental Neuroscience (PEN)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This chapter describes lymphocyte maturation and differentiation. Interactions of lymphoid tissues with the central and peripheral nervous systems play a fundamental role in health and disease. Recent advances in xenobiology has opened new approaches to study relationships between peripheral immunity and nervous system development, homeostasis, response to injuries, and disease in animal models. Humanized animal models help to study the complexity of human immune system development and adaptive immune responses. Humanization of a mouse brain with human glial cells provides an additional tool to study hemato-lymphoid brain interactions in small animals.

Original language	English (US)
Title of host publication	Neuroimmune Pharmacology
Publisher	Springer International Publishing
Pages	201-216
Number of pages	16
ISBN (Electronic)	9783319440224
ISBN (Print)	9783319440200
DOIs	https://doi.org/10.1007/978-3-319-44022-4_14
State	Published - Jan 1 2016

Keywords

Antibodies
B cells
Effector memory T cells
Follicular dendritic cells (FDCs)
Immune priledged
Regulatory T cells
Stat4
Stat6
T-Bet

ASJC Scopus subject areas

General Immunology and Microbiology
General Pharmacology, Toxicology and Pharmaceutics
General Neuroscience
General Medicine

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10.1007/978-3-319-44022-4_14

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AB - This chapter describes lymphocyte maturation and differentiation. Interactions of lymphoid tissues with the central and peripheral nervous systems play a fundamental role in health and disease. Recent advances in xenobiology has opened new approaches to study relationships between peripheral immunity and nervous system development, homeostasis, response to injuries, and disease in animal models. Humanized animal models help to study the complexity of human immune system development and adaptive immune responses. Humanization of a mouse brain with human glial cells provides an additional tool to study hemato-lymphoid brain interactions in small animals.

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KW - B cells

KW - Effector memory T cells

KW - Follicular dendritic cells (FDCs)

KW - Immune priledged

KW - Regulatory T cells

KW - Stat4

KW - Stat6

KW - T-Bet

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BT - Neuroimmune Pharmacology

PB - Springer International Publishing

ER -

Human lymphocyte biology and its application to humanized mice

Abstract

Keywords

ASJC Scopus subject areas

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