Human papillomavirus in oropharyngeal squamous cell carcinomas in korea: Use of G1 cycle markers as new prognosticators

Weon Seo Park; Junsun Ryu; Kwan Ho Cho; Moon Kyung Choi; Sung Ho Moon; Tak Yun; Byung Sam Chun; Geon Kook Lee; Hyun Joo Ahn; John H. Lee; Paola Vermeer; Yuh Seog Jung

doi:10.1002/hed.21939

Human papillomavirus in oropharyngeal squamous cell carcinomas in korea: Use of G1 cycle markers as new prognosticators

Weon Seo Park, Junsun Ryu, Kwan Ho Cho, Moon Kyung Choi, Sung Ho Moon, Tak Yun, Byung Sam Chun, Geon Kook Lee, Hyun Joo Ahn, John H. Lee, Paola Vermeer, Yuh Seog Jung

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) exhibits distinct patterns worldwide, but its prevalence has not been extensively evaluated in Korea. The E7 oncogene-mediated carcinogenesis and its meaning are yet to be uncovered for oropharyngeal SCCs. Methods In a Korean oropharyngeal SCC cohort, epidemiological indicators, HPV, and G1 cell cycle marker expressions were correlated with survival. Results Among 93 surgically treated patients with oropharyngeal SCCs, 49.5% were HPV+, which were significantly younger, and predominantly nonsmoking. They demonstrated better survival than HPV- (94% vs 60%). Patients who were HPV+ with oropharyngeal SCCs expressed higher p16, cyclin-dependent kinase 4 (cdk4), and lower pRb. The p16 (hazard ratio [HR] 2.39), pRb (HR 2.13), and CCND1 (HR 2.09) correlated with survival. Notably, combined markers like p16/cdk4 ratio (HR 2.47) and cdk4+CCND1 sum (HR 2.65) were more significantly correlated. Conclusion Incidence of HPV-related oropharyngeal SCC in Korea is similar to U.S.-European data. HPV presence correlates with improved survival. Expression ratios of G1 markers may predict survival of oropharyngeal SCCs better than each marker alone.

Original language	English (US)
Pages (from-to)	1408-1417
Number of pages	10
Journal	Head and Neck
Volume	34
Issue number	10
DOIs	https://doi.org/10.1002/hed.21939
State	Published - Oct 2012
Externally published	Yes

Keywords

CCND1 protein
cdk4 protein
human papillomavirus
oropharyngeal cancer
p16 protein

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.21939

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Human papillomavirus in oropharyngeal squamous cell carcinomas in korea : Use of G1 cycle markers as new prognosticators. / Park, Weon Seo; Ryu, Junsun; Cho, Kwan Ho; Choi, Moon Kyung; Moon, Sung Ho; Yun, Tak; Chun, Byung Sam; Lee, Geon Kook; Ahn, Hyun Joo; Lee, John H.; Vermeer, Paola; Jung, Yuh Seog.

In: Head and Neck, Vol. 34, No. 10, 10.2012, p. 1408-1417.

Research output: Contribution to journal › Article › peer-review

Park, Weon Seo ; Ryu, Junsun ; Cho, Kwan Ho ; Choi, Moon Kyung ; Moon, Sung Ho ; Yun, Tak ; Chun, Byung Sam ; Lee, Geon Kook ; Ahn, Hyun Joo ; Lee, John H. ; Vermeer, Paola ; Jung, Yuh Seog. / Human papillomavirus in oropharyngeal squamous cell carcinomas in korea : Use of G1 cycle markers as new prognosticators. In: Head and Neck. 2012 ; Vol. 34, No. 10. pp. 1408-1417.

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title = "Human papillomavirus in oropharyngeal squamous cell carcinomas in korea: Use of G1 cycle markers as new prognosticators",

abstract = "Background Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) exhibits distinct patterns worldwide, but its prevalence has not been extensively evaluated in Korea. The E7 oncogene-mediated carcinogenesis and its meaning are yet to be uncovered for oropharyngeal SCCs. Methods In a Korean oropharyngeal SCC cohort, epidemiological indicators, HPV, and G1 cell cycle marker expressions were correlated with survival. Results Among 93 surgically treated patients with oropharyngeal SCCs, 49.5% were HPV+, which were significantly younger, and predominantly nonsmoking. They demonstrated better survival than HPV- (94% vs 60%). Patients who were HPV+ with oropharyngeal SCCs expressed higher p16, cyclin-dependent kinase 4 (cdk4), and lower pRb. The p16 (hazard ratio [HR] 2.39), pRb (HR 2.13), and CCND1 (HR 2.09) correlated with survival. Notably, combined markers like p16/cdk4 ratio (HR 2.47) and cdk4+CCND1 sum (HR 2.65) were more significantly correlated. Conclusion Incidence of HPV-related oropharyngeal SCC in Korea is similar to U.S.-European data. HPV presence correlates with improved survival. Expression ratios of G1 markers may predict survival of oropharyngeal SCCs better than each marker alone.",

keywords = "CCND1 protein, cdk4 protein, human papillomavirus, oropharyngeal cancer, p16 protein",

author = "Park, {Weon Seo} and Junsun Ryu and Cho, {Kwan Ho} and Choi, {Moon Kyung} and Moon, {Sung Ho} and Tak Yun and Chun, {Byung Sam} and Lee, {Geon Kook} and Ahn, {Hyun Joo} and Lee, {John H.} and Paola Vermeer and Jung, {Yuh Seog}",

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doi = "10.1002/hed.21939",

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AU - Choi, Moon Kyung

AU - Moon, Sung Ho

AU - Yun, Tak

AU - Chun, Byung Sam

AU - Lee, Geon Kook

AU - Ahn, Hyun Joo

AU - Lee, John H.

AU - Vermeer, Paola

AU - Jung, Yuh Seog

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N2 - Background Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) exhibits distinct patterns worldwide, but its prevalence has not been extensively evaluated in Korea. The E7 oncogene-mediated carcinogenesis and its meaning are yet to be uncovered for oropharyngeal SCCs. Methods In a Korean oropharyngeal SCC cohort, epidemiological indicators, HPV, and G1 cell cycle marker expressions were correlated with survival. Results Among 93 surgically treated patients with oropharyngeal SCCs, 49.5% were HPV+, which were significantly younger, and predominantly nonsmoking. They demonstrated better survival than HPV- (94% vs 60%). Patients who were HPV+ with oropharyngeal SCCs expressed higher p16, cyclin-dependent kinase 4 (cdk4), and lower pRb. The p16 (hazard ratio [HR] 2.39), pRb (HR 2.13), and CCND1 (HR 2.09) correlated with survival. Notably, combined markers like p16/cdk4 ratio (HR 2.47) and cdk4+CCND1 sum (HR 2.65) were more significantly correlated. Conclusion Incidence of HPV-related oropharyngeal SCC in Korea is similar to U.S.-European data. HPV presence correlates with improved survival. Expression ratios of G1 markers may predict survival of oropharyngeal SCCs better than each marker alone.

AB - Background Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) exhibits distinct patterns worldwide, but its prevalence has not been extensively evaluated in Korea. The E7 oncogene-mediated carcinogenesis and its meaning are yet to be uncovered for oropharyngeal SCCs. Methods In a Korean oropharyngeal SCC cohort, epidemiological indicators, HPV, and G1 cell cycle marker expressions were correlated with survival. Results Among 93 surgically treated patients with oropharyngeal SCCs, 49.5% were HPV+, which were significantly younger, and predominantly nonsmoking. They demonstrated better survival than HPV- (94% vs 60%). Patients who were HPV+ with oropharyngeal SCCs expressed higher p16, cyclin-dependent kinase 4 (cdk4), and lower pRb. The p16 (hazard ratio [HR] 2.39), pRb (HR 2.13), and CCND1 (HR 2.09) correlated with survival. Notably, combined markers like p16/cdk4 ratio (HR 2.47) and cdk4+CCND1 sum (HR 2.65) were more significantly correlated. Conclusion Incidence of HPV-related oropharyngeal SCC in Korea is similar to U.S.-European data. HPV presence correlates with improved survival. Expression ratios of G1 markers may predict survival of oropharyngeal SCCs better than each marker alone.

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