Human primary gastric dendritic cells induce a Th1 response to H. pylori

D. Bimczok, R. H. Clements, K. B. Waites, L. Novak, D. E. Eckhoff, P. J. Mannon, P. D. Smith, L. E. Smythies

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Adaptive CD4 T-cell responses are important in the pathogenesis of chronic Helicobacter pylori gastritis. However, the gastric antigen-presenting cells that induce these responses have not yet been identified. Here we show that dendritic cells (DCs) are present in the gastric mucosa of healthy subjects and are more prevalent and more activated in the gastric mucosa of H. pylori-infected subjects. H. pylori induced gastric DCs isolated from noninfected subjects to express increased levels of CD11c, CD86 and CD83, and to secrete proinflammatory cytokines, particularly interleukin (IL)-6 and IL-8. Importantly, gastric DCs pulsed with live H. pylori, but not control DCs, mediated T-cell secretion of interferon-γ. The ability of H. pylori to induce gastric DC maturation and stimulate gastric DC activation of Th1 cells implicates gastric DCs as initiators of the immune response to H. pylori.

Original languageEnglish (US)
Pages (from-to)260-269
Number of pages10
JournalMucosal Immunology
Volume3
Issue number3
DOIs
StatePublished - May 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Human primary gastric dendritic cells induce a Th1 response to H. pylori'. Together they form a unique fingerprint.

  • Cite this

    Bimczok, D., Clements, R. H., Waites, K. B., Novak, L., Eckhoff, D. E., Mannon, P. J., Smith, P. D., & Smythies, L. E. (2010). Human primary gastric dendritic cells induce a Th1 response to H. pylori. Mucosal Immunology, 3(3), 260-269. https://doi.org/10.1038/mi.2010.10