Human prostate cancer cells: Inhibition of proliferation by vitamin D analogs

G. G. Schwartz, T. A. Oeler, M. R. Uskokovic, R. R. Bahnson

Research output: Contribution to journalArticle

136 Scopus citations

Abstract

1,25-Dihydroxyvitamin D [1,25(0H)2D3, calcitriol] can inhibit the proliferation of some human prostate cancer cells but its clinical use is limited by hypercalcemia. We therefore explored the bioactivity of less calcemic vitamin D analogs. We studied the effects of calcitriol and 3 synthetic analogs at concentrations of 10-6 to 10-12 M on the in vitro proliferation of 3 human prostate carcinoma cell lines: DU 145, PC-3, and LNCaP. Calcitriol and analogs showed significant antiproliferative activity on PC-3 and LNCaP cells. DU 145 cells were inhibited by the analogs only. We conclude that vitamin D analogs warrant further investigation as therapeutic agents in prostate cancer.

Original languageEnglish (US)
Pages (from-to)1077-1081
Number of pages5
JournalAnticancer Research
Volume14
Issue number3 A
StatePublished - Jan 1 1994

Keywords

  • Hormones
  • Prostatic neoplasms
  • Therapeutics
  • Vitamin D analogs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Schwartz, G. G., Oeler, T. A., Uskokovic, M. R., & Bahnson, R. R. (1994). Human prostate cancer cells: Inhibition of proliferation by vitamin D analogs. Anticancer Research, 14(3 A), 1077-1081.