Human prostate cancer cells: Inhibition of proliferation by vitamin D analogs

G. G. Schwartz, T. A. Oeler, M. R. Uskokovic, R. R. Bahnson

Research output: Contribution to journalArticlepeer-review

136 Scopus citations


1,25-Dihydroxyvitamin D [1,25(0H)2D3, calcitriol] can inhibit the proliferation of some human prostate cancer cells but its clinical use is limited by hypercalcemia. We therefore explored the bioactivity of less calcemic vitamin D analogs. We studied the effects of calcitriol and 3 synthetic analogs at concentrations of 10-6 to 10-12 M on the in vitro proliferation of 3 human prostate carcinoma cell lines: DU 145, PC-3, and LNCaP. Calcitriol and analogs showed significant antiproliferative activity on PC-3 and LNCaP cells. DU 145 cells were inhibited by the analogs only. We conclude that vitamin D analogs warrant further investigation as therapeutic agents in prostate cancer.

Original languageEnglish (US)
Pages (from-to)1077-1081
Number of pages5
JournalAnticancer Research
Issue number3 A
StatePublished - 1994
Externally publishedYes


  • Hormones
  • Prostatic neoplasms
  • Therapeutics
  • Vitamin D analogs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Human prostate cancer cells: Inhibition of proliferation by vitamin D analogs'. Together they form a unique fingerprint.

Cite this