Human serum paraoxonase (PON1): Identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis

Keyphrases

• Amino Acid Residues 100%
• Human Serum 100%
• Site-directed mutagenesis 100%
• Selective Labeling 100%
• Paraoxonase 1 (PON1) 100%
• Serum Paraoxonase 100%
• Group-specific 40%
• Paraoxon 40%
• Specific Labeling 40%
• Labeling Experiment 20%
• Mutant Protein 20%
• 3D Structure 20%
• Conformational Change 20%
• Native Enzymes 20%
• Misfolding 20%
• HEK293 Cells 20%
• Active Sites 20%
• Organophosphate 20%
• Catalytic Properties 20%
• Soman 20%
• Sarin 20%
• Nucleophilic 20%
• Mutation Effect 20%
• Substrate Binding 20%
• Chlorpyrifos-oxon 20%
• Diazoxon 20%
• Calcium-dependent 20%
• Complementary Approach 20%
• Catalytic Constant 20%
• Phenylacetate 20%
• Arylesterase 20%

Biochemistry, Genetics and Molecular Biology

• Serum (Blood) 100%
• Site-Directed Mutagenesis 100%
• PON1 100%
• Paraoxonase 100%
• Aryldialkylphosphatase 100%
• Essential Amino Acid 100%
• Enzyme 40%
• Wild Type 20%
• Mutant Protein 20%
• Conformational Change 20%
• Enzymatic Hydrolysis 20%
• Active Site 20%
• Soman 20%
• Chlorpyrifos 20%
• Nucleophilicity 20%
• Arylesterase 20%

Immunology and Microbiology

• Serum (Blood) 100%
• Site Directed Mutagenesis 100%
• Wild Type 33%
• Conformational Transition 33%
• Hydrolysis 33%
• Ribomunyl 33%
• Nucleophilicity 33%