Hyaluronan synthase of chlorella virus PBCV-1

Paul L. DeAngelis, Wei Jing, Michael V. Graves, Dwight E. Burbank, James L. Van Etten

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations


Sequence analysis of the 330-kilobase genome of the virus PBCV-1 that infects a chlorella-like green algae revealed an open reading frame, A98R, with similarity to several hyaluronan synthases. Hyaluronan is an essential polysaccharide found in higher animals as well as in a few pathogenic bacteria. Expression of the A98R gene product in Escherichia coli indicated that the recombinant protein is an authentic hyaluronan synthase. A98R is expressed early in PBCV-1 infection and hyaluronan is produced in infected algae. These results demonstrate that a virus can encode an enzyme capable of synthesizing a carbohydrate polymer and that hyaluronan exists outside of animals and their pathogens.

Original languageEnglish (US)
Pages (from-to)1800-1803
Number of pages4
Issue number5344
StatePublished - Dec 5 1997

ASJC Scopus subject areas

  • General


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