Hyaluronic acid as a bioactive component for bone tissue regeneration: Fabrication, modification, properties, and biological functions

Fei Xing, Changchun Zhou, Didi Hui, Colin Du, Lina Wu, Linnan Wang, Wenzhao Wang, Xiaobing Pu, Linxia Gu, Lei Liu, Zhou Xiang, Xingdong Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Hyaluronic acid (HA) is widely distributed in the human body, and it is heavily involved in many physiological functions such as tissue hydration, wound repair, and cell migration. In recent years, HA and its derivatives have been widely used as advanced bioactive polymers for bone regeneration. Many medical products containing HA have been developed because this natural polymer has been proven to be nontoxic, noninflammatory, biodegradable, and biocompatible. Moreover, HA-based composite scaffolds have shown good potential for promoting osteogenesis and mineralization. Recently, many HA-based biomaterials have been fabricated for bone regeneration by combining with electrospinning and 3D printing technology. In this review, the polymer structures, processing, properties, and applications in bone tissue engineering are summarized. The challenges and prospects of HA polymers are also discussed.

Original languageEnglish (US)
Pages (from-to)1059-1079
Number of pages21
JournalNanotechnology Reviews
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • 3D printing
  • bioactive component
  • bone regeneration
  • hyaluronic acid
  • tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Materials Science (miscellaneous)
  • Energy Engineering and Power Technology
  • Engineering (miscellaneous)
  • Process Chemistry and Technology

Fingerprint Dive into the research topics of 'Hyaluronic acid as a bioactive component for bone tissue regeneration: Fabrication, modification, properties, and biological functions'. Together they form a unique fingerprint.

Cite this