TY - JOUR
T1 - Hyaluronic acid as a bioactive component for bone tissue regeneration
T2 - Fabrication, modification, properties, and biological functions
AU - Xing, Fei
AU - Zhou, Changchun
AU - Hui, Didi
AU - Du, Colin
AU - Wu, Lina
AU - Wang, Linnan
AU - Wang, Wenzhao
AU - Pu, Xiaobing
AU - Gu, Linxia
AU - Liu, Lei
AU - Xiang, Zhou
AU - Zhang, Xingdong
N1 - Funding Information:
This work was partially supported by the National Key Research and Development Program of China (No. 2018YFC1106800 and 2018YFB1105600), National Natural Science Foundation of China (31971251 and 31870961), and Sichuan Province Science & Technology Department Projects (2019YFH0079, 2016CZYD0004, 2019JDTD0008, 2020YFS0036, and 2020YFS0462).
Publisher Copyright:
© 2020 Fei Xing et al., published by De Gruyter 2020.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Hyaluronic acid (HA) is widely distributed in the human body, and it is heavily involved in many physiological functions such as tissue hydration, wound repair, and cell migration. In recent years, HA and its derivatives have been widely used as advanced bioactive polymers for bone regeneration. Many medical products containing HA have been developed because this natural polymer has been proven to be nontoxic, noninflammatory, biodegradable, and biocompatible. Moreover, HA-based composite scaffolds have shown good potential for promoting osteogenesis and mineralization. Recently, many HA-based biomaterials have been fabricated for bone regeneration by combining with electrospinning and 3D printing technology. In this review, the polymer structures, processing, properties, and applications in bone tissue engineering are summarized. The challenges and prospects of HA polymers are also discussed.
AB - Hyaluronic acid (HA) is widely distributed in the human body, and it is heavily involved in many physiological functions such as tissue hydration, wound repair, and cell migration. In recent years, HA and its derivatives have been widely used as advanced bioactive polymers for bone regeneration. Many medical products containing HA have been developed because this natural polymer has been proven to be nontoxic, noninflammatory, biodegradable, and biocompatible. Moreover, HA-based composite scaffolds have shown good potential for promoting osteogenesis and mineralization. Recently, many HA-based biomaterials have been fabricated for bone regeneration by combining with electrospinning and 3D printing technology. In this review, the polymer structures, processing, properties, and applications in bone tissue engineering are summarized. The challenges and prospects of HA polymers are also discussed.
KW - 3D printing
KW - bioactive component
KW - bone regeneration
KW - hyaluronic acid
KW - tissue engineering
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U2 - 10.1515/ntrev-2020-0084
DO - 10.1515/ntrev-2020-0084
M3 - Article
AN - SCOPUS:85096300744
VL - 9
SP - 1059
EP - 1079
JO - Nanotechnology Reviews
JF - Nanotechnology Reviews
SN - 2191-9089
IS - 1
ER -