Hybrid Donor-Acceptor Polymer Particles with Amplified Energy Transfer for Detection and On-Demand Treatment of Breast Cancer

Elizabeth Graham-Gurysh, Sneha Kelkar, Eleanor McCabe-Lankford, Narayanan Kuthirummal, Theodore Brown, Nancy D. Kock, Aaron M. Mohs, Nicole Levi-Polyachenko

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Judicious combination of semiconducting polymers with alternating electron donor (D) and acceptor (A) segments created hybrid nanoparticles with amplified energy transfer and red-shifted emission, while simultaneously providing photothermal capabilities. Hybrid D-A polymer particles (H-DAPPs) passively localized within orthotopic breast tumors, serving as bright fluorescent beacons. Laser stimulation induced heat generation on par with gold nanorods, resulting in selective destruction of the tumor. H-DAPPs can also undergo multiple thermal treatments, with no loss of fluorescence intensity or photothermal potential. These results indicate that H-DAPPs provide new avenues for the synthesis of hybrid nanoparticles useful in localized detection and treatment of disease.

Original languageEnglish (US)
Pages (from-to)7697-7703
Number of pages7
JournalACS Applied Materials and Interfaces
Volume10
Issue number9
DOIs
StatePublished - Mar 7 2018

ASJC Scopus subject areas

  • Materials Science(all)

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