TY - JOUR
T1 - Hybrid Donor-Acceptor Polymer Particles with Amplified Energy Transfer for Detection and On-Demand Treatment of Breast Cancer
AU - Graham-Gurysh, Elizabeth
AU - Kelkar, Sneha
AU - McCabe-Lankford, Eleanor
AU - Kuthirummal, Narayanan
AU - Brown, Theodore
AU - Kock, Nancy D.
AU - Mohs, Aaron M.
AU - Levi-Polyachenko, Nicole
N1 - Funding Information:
This work was supported by funding from the NIH Grant R21 EB019748-02. The authors acknowledge the use of Wake Forest’s Cell Viral Vector Core Laboratory (supported by NCI CCSG P30CA012197) for supplying tissue culture media and reagents. The authors thank Ravi Singh at Wake Forest University Health Sciences for use of the Malvern Instruments Zetasizer Nano-ZS90 dynamic light scattering system, and Dr. Metheny-Barlow at Wake Forest University Health Sciences for EO771 cells.
Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/3/7
Y1 - 2018/3/7
N2 - Judicious combination of semiconducting polymers with alternating electron donor (D) and acceptor (A) segments created hybrid nanoparticles with amplified energy transfer and red-shifted emission, while simultaneously providing photothermal capabilities. Hybrid D-A polymer particles (H-DAPPs) passively localized within orthotopic breast tumors, serving as bright fluorescent beacons. Laser stimulation induced heat generation on par with gold nanorods, resulting in selective destruction of the tumor. H-DAPPs can also undergo multiple thermal treatments, with no loss of fluorescence intensity or photothermal potential. These results indicate that H-DAPPs provide new avenues for the synthesis of hybrid nanoparticles useful in localized detection and treatment of disease.
AB - Judicious combination of semiconducting polymers with alternating electron donor (D) and acceptor (A) segments created hybrid nanoparticles with amplified energy transfer and red-shifted emission, while simultaneously providing photothermal capabilities. Hybrid D-A polymer particles (H-DAPPs) passively localized within orthotopic breast tumors, serving as bright fluorescent beacons. Laser stimulation induced heat generation on par with gold nanorods, resulting in selective destruction of the tumor. H-DAPPs can also undergo multiple thermal treatments, with no loss of fluorescence intensity or photothermal potential. These results indicate that H-DAPPs provide new avenues for the synthesis of hybrid nanoparticles useful in localized detection and treatment of disease.
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U2 - 10.1021/acsami.7b19503
DO - 10.1021/acsami.7b19503
M3 - Article
C2 - 29457709
AN - SCOPUS:85043342816
SN - 1944-8244
VL - 10
SP - 7697
EP - 7703
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
IS - 9
ER -