Hybrid spectral micro-CT: System design, implementation, and preliminary results

James R. Bennett, Alex M.T. Opie, Qiong Xu, Hengyong Yu, Michael Walsh, Anthony Butler, Phillip Butler, Guohua Cao, Aaron Mohs, Ge Wang

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Spectral CT has proven an important development in biomedical imaging, and there have been several publications in the past years demonstrating its merits in pre-clinical and clinical applications. In 2012, Xu reported that near-term implementation of spectral micro-CT could be enhanced by a hybrid architecture: a narrow-beam spectral "interior" imaging chain integrated with a traditional wide-beam "global" imaging chain. This hybrid integration coupled with compressive sensing (CS)-based interior tomography demonstrated promising results for improved contrast resolution, and decreased system cost and radiation dose. The motivation for the current study is implementation and evaluation of the hybrid architecture with a first-of-its-kind hybrid spectral micro-CT system. Preliminary results confirm improvements in both contrast and spatial resolution. This technology is shown to merit further investigation and potential application in future spectral CT scanner design.

Original languageEnglish (US)
Article number6587073
Pages (from-to)246-253
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Issue number2
StatePublished - Feb 2014
Externally publishedYes


  • CT architecture
  • CT instrumentation
  • interior tomography
  • micro-CT
  • spectral-CT

ASJC Scopus subject areas

  • Biomedical Engineering


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