Hydrogels for vocal fold tissue engineering and repair

Mariah Hahn; Benjamin Teply; Alisha Sieminski; Molly Stevens; Roger Kamm; Steven Zeitels; Robert Langer

Hydrogels for vocal fold tissue engineering and repair

Mariah Hahn, Benjamin Teply, Alisha Sieminski, Molly Stevens, Roger Kamm, Steven Zeitels, Robert Langer

Research output: Contribution to conference › Paper › peer-review

Abstract

The potential of self-assembling peptides RAD-16-II and collagen-alginate composites to maintain vocal fibroblasts and stimulate the synthesis and accumulation of ECM in 3D cell culture with minimal matrix contraction was demonstrated. The peptide RAD-16-II represents one of a class of self-assembling peptides developed through molecular engineering. These peptides were found to assemble into well-ordered nano-fibers with inter-fiber spacing of ∼50-20 nm, creating a nanoscale hydrogel network around encapsulated cells. Alginate was studied extensively as a tissue engineering matrix for cartilage and for soft tissue augmentation.

Original language	English (US)
Pages	1205-1212
Number of pages	8
State	Published - 2004
Externally published	Yes
Event	2004 AIChE Annual Meeting - Austin, TX, United States Duration: Nov 7 2004 → Nov 12 2004

Conference

Conference	2004 AIChE Annual Meeting
Country/Territory	United States
City	Austin, TX
Period	11/7/04 → 11/12/04

ASJC Scopus subject areas

General Engineering

Cite this

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title = "Hydrogels for vocal fold tissue engineering and repair",

abstract = "The potential of self-assembling peptides RAD-16-II and collagen-alginate composites to maintain vocal fibroblasts and stimulate the synthesis and accumulation of ECM in 3D cell culture with minimal matrix contraction was demonstrated. The peptide RAD-16-II represents one of a class of self-assembling peptides developed through molecular engineering. These peptides were found to assemble into well-ordered nano-fibers with inter-fiber spacing of ∼50-20 nm, creating a nanoscale hydrogel network around encapsulated cells. Alginate was studied extensively as a tissue engineering matrix for cartilage and for soft tissue augmentation.",

author = "Mariah Hahn and Benjamin Teply and Alisha Sieminski and Molly Stevens and Roger Kamm and Steven Zeitels and Robert Langer",

year = "2004",

language = "English (US)",

pages = "1205--1212",

note = "2004 AIChE Annual Meeting ; Conference date: 07-11-2004 Through 12-11-2004",

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TY - CONF

T1 - Hydrogels for vocal fold tissue engineering and repair

AU - Hahn, Mariah

AU - Teply, Benjamin

AU - Sieminski, Alisha

AU - Stevens, Molly

AU - Kamm, Roger

AU - Zeitels, Steven

AU - Langer, Robert

PY - 2004

Y1 - 2004

N2 - The potential of self-assembling peptides RAD-16-II and collagen-alginate composites to maintain vocal fibroblasts and stimulate the synthesis and accumulation of ECM in 3D cell culture with minimal matrix contraction was demonstrated. The peptide RAD-16-II represents one of a class of self-assembling peptides developed through molecular engineering. These peptides were found to assemble into well-ordered nano-fibers with inter-fiber spacing of ∼50-20 nm, creating a nanoscale hydrogel network around encapsulated cells. Alginate was studied extensively as a tissue engineering matrix for cartilage and for soft tissue augmentation.

AB - The potential of self-assembling peptides RAD-16-II and collagen-alginate composites to maintain vocal fibroblasts and stimulate the synthesis and accumulation of ECM in 3D cell culture with minimal matrix contraction was demonstrated. The peptide RAD-16-II represents one of a class of self-assembling peptides developed through molecular engineering. These peptides were found to assemble into well-ordered nano-fibers with inter-fiber spacing of ∼50-20 nm, creating a nanoscale hydrogel network around encapsulated cells. Alginate was studied extensively as a tissue engineering matrix for cartilage and for soft tissue augmentation.

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UR - http://www.scopus.com/inward/citedby.url?scp=22544434965&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:22544434965

SP - 1205

EP - 1212

T2 - 2004 AIChE Annual Meeting

Y2 - 7 November 2004 through 12 November 2004

ER -

Hydrogels for vocal fold tissue engineering and repair

Abstract

Conference

ASJC Scopus subject areas

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