Hydrogels for vocal fold tissue engineering and repair

Mariah Hahn, Benjamin Teply, Alisha Sieminski, Molly Stevens, Roger Kamm, Steven Zeitels, Robert Langer

Research output: Contribution to conferencePaper

Abstract

The potential of self-assembling peptides RAD-16-II and collagen-alginate composites to maintain vocal fibroblasts and stimulate the synthesis and accumulation of ECM in 3D cell culture with minimal matrix contraction was demonstrated. The peptide RAD-16-II represents one of a class of self-assembling peptides developed through molecular engineering. These peptides were found to assemble into well-ordered nano-fibers with inter-fiber spacing of ∼50-20 nm, creating a nanoscale hydrogel network around encapsulated cells. Alginate was studied extensively as a tissue engineering matrix for cartilage and for soft tissue augmentation.

Original languageEnglish (US)
Pages1205-1212
Number of pages8
StatePublished - 2004
Externally publishedYes
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004

Conference

Conference2004 AIChE Annual Meeting
CountryUnited States
CityAustin, TX
Period11/7/0411/12/04

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Hahn, M., Teply, B., Sieminski, A., Stevens, M., Kamm, R., Zeitels, S., & Langer, R. (2004). Hydrogels for vocal fold tissue engineering and repair. 1205-1212. Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.