Hyperglycemia-induced cardiac contractile dysfunction in the diabetic heart

Raphael M. Singh, Tahreem Waqar, Frank C. Howarth, Ernest Adeghate, Keshore Bidasee, Jaipaul Singh

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart leading to a reduction in contractile dysfunction. Defects in ryanodine receptor, reduced activity of the sarcoplasmic reticulum calcium pump (SERCA) and, along with reduced activity of the sodium-calcium exchanger (NCX) and alterations in myofilament, collectively cause a calcium imbalance within the diabetic cardiomyocytes. This in turn is characterized by cytosolic calcium overloading or elevated diastolic calcium leading to heart failure. Numerous studies have been performed to identify the cellular, subcellular, and molecular derangements in diabetes-induced cardiomyopathy (DCM), but the precise mechanism(s) is still unknown. This review focuses on the mechanism behind DCM, the onset of contractile dysfunction, and the associated changes with special emphasis on hyperglycemia, mitochondrial dysfunction in the diabetic heart. Further, management strategies, including treatment and emerging therapeutic modalities, are discussed.

Original languageEnglish (US)
Pages (from-to)37-54
Number of pages18
JournalHeart Failure Reviews
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • Calcium transients [Ca]
  • Contractile dysfunction
  • Diabetic cardiomyopathy
  • Hyperglycemia
  • Sarcoplasmic reticulum calcium ATPase (SERCA)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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