Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The explanation of hypersensitivity reactions has long relied on the classification of Gell and Coombs, originally proposed in the 1960s. However, their concepts were predated by other authors by at least 50 years. A 21st century pediatric allergy clinic provides multiple examples of these basic concepts on a daily basis. We review classic and less classic examples of the original criteria, highlight where current disease pathophysiology does not always fit the original model, and provide updated language for common and uncommon immunologically driven hypersensitivity diseases.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalPediatric, Allergy, Immunology, and Pulmonology
Issue number1
StatePublished - Mar 2020


  • B cells
  • IgE
  • T cells
  • hypersensitivity
  • immune
  • immunity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics'. Together they form a unique fingerprint.

Cite this