Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics

Russell J. Hopp

doi:10.1089/ped.2019.1109

Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics

Research output: Contribution to journal › Article

Abstract

The explanation of hypersensitivity reactions has long relied on the classification of Gell and Coombs, originally proposed in the 1960s. However, their concepts were predated by other authors by at least 50 years. A 21st century pediatric allergy clinic provides multiple examples of these basic concepts on a daily basis. We review classic and less classic examples of the original criteria, highlight where current disease pathophysiology does not always fit the original model, and provide updated language for common and uncommon immunologically driven hypersensitivity diseases.

Original language	English (US)
Pages (from-to)	12-18
Number of pages	7
Journal	Pediatric, Allergy, Immunology, and Pulmonology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1089/ped.2019.1109
State	Published - Mar 2020

Keywords

B cells
IgE
T cells
hypersensitivity
immune
immunity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Pulmonary and Respiratory Medicine

Access to Document

10.1089/ped.2019.1109

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Hopp, R. J. (2020). Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics. Pediatric, Allergy, Immunology, and Pulmonology, 33(1), 12-18. https://doi.org/10.1089/ped.2019.1109

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