Hypersensitivity reactions to trimetrexate

Jean L. Grem, Susan A. King, Mary E. Costanza, Thomas D. Brown

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Trimetrexate is a nonclassical antifol currently being tested for efficacy in cancer patients and as an antiparasitic agent against Pneumocystis carinii pneumonia in AIDS patients. We have now received the first reports of hypersensitivity reactions in Phase II cancer trials. Two types of reactions were noted. The most severe reaction, immediate hypotension with loss of consciousness, occurred in only one patient. Four other patients exhibited an immediate systemic effect with one or more of the following symptoms: facial flushing, fever, shaking, pruritus, bronchospasm, periorbital edema, and difficulty in swallowing. Immediate hypersensitivity should now be considered a known side effect of trimetrexate therapy, occurring in < 2% of patients.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalInvestigational New Drugs
Issue number2
StatePublished - May 1990
Externally publishedYes


  • hypersensitivity
  • trimetrexate

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)


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