Hypoglycaemic activity of some medicinal plants in Sri-Lanka

M. R. Fernando; M. I. Thabrew; E. H. Karunanayake

doi:10.1016/0306-3623(90)91033-N

Hypoglycaemic activity of some medicinal plants in Sri-Lanka

M. R. Fernando, M. I. Thabrew, E. H. Karunanayake

Obstetrics/Gynecology

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Abstract

1. Investigations were carried out to determine whether aqueous extracts of Osbeckia octandra, Artocarpus heterophyllus and Bambusa vulgaris truly possess oral hypoglycaemic activity. 2. All three plant extracts significantly lowered the fasting blood glucose level and markedly improved glucose tolerance in Sprague-Dawley rats. 3. A maximum hypoglycaemic activity was observed at + 3 hr with O. octandra and B. vulgaris; with A. heterophyllus a maximum effect was not observed even at + 5 hr. 4. The hypoglycaemic activity of O. octandra was comparable with that of tolbutamide while that of A. heterophyllus or B. vulgaris was better than that of tolbutamide. 5. The magnitude of the hypoglycaemic effects varied with the dosage used and the time of storage (except with A. heterophyllus, whose activity did not change with storage even up to 3 days).

Original language	English (US)
Pages (from-to)	779-782
Number of pages	4
Journal	General Pharmacology
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/0306-3623(90)91033-N
State	Published - 1990

ASJC Scopus subject areas

Pharmacology

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10.1016/0306-3623(90)91033-N

Cite this

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title = "Hypoglycaemic activity of some medicinal plants in Sri-Lanka",

abstract = "1. Investigations were carried out to determine whether aqueous extracts of Osbeckia octandra, Artocarpus heterophyllus and Bambusa vulgaris truly possess oral hypoglycaemic activity. 2. All three plant extracts significantly lowered the fasting blood glucose level and markedly improved glucose tolerance in Sprague-Dawley rats. 3. A maximum hypoglycaemic activity was observed at + 3 hr with O. octandra and B. vulgaris; with A. heterophyllus a maximum effect was not observed even at + 5 hr. 4. The hypoglycaemic activity of O. octandra was comparable with that of tolbutamide while that of A. heterophyllus or B. vulgaris was better than that of tolbutamide. 5. The magnitude of the hypoglycaemic effects varied with the dosage used and the time of storage (except with A. heterophyllus, whose activity did not change with storage even up to 3 days).",

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T1 - Hypoglycaemic activity of some medicinal plants in Sri-Lanka

AU - Fernando, M. R.

AU - Thabrew, M. I.

AU - Karunanayake, E. H.

PY - 1990

Y1 - 1990

N2 - 1. Investigations were carried out to determine whether aqueous extracts of Osbeckia octandra, Artocarpus heterophyllus and Bambusa vulgaris truly possess oral hypoglycaemic activity. 2. All three plant extracts significantly lowered the fasting blood glucose level and markedly improved glucose tolerance in Sprague-Dawley rats. 3. A maximum hypoglycaemic activity was observed at + 3 hr with O. octandra and B. vulgaris; with A. heterophyllus a maximum effect was not observed even at + 5 hr. 4. The hypoglycaemic activity of O. octandra was comparable with that of tolbutamide while that of A. heterophyllus or B. vulgaris was better than that of tolbutamide. 5. The magnitude of the hypoglycaemic effects varied with the dosage used and the time of storage (except with A. heterophyllus, whose activity did not change with storage even up to 3 days).

AB - 1. Investigations were carried out to determine whether aqueous extracts of Osbeckia octandra, Artocarpus heterophyllus and Bambusa vulgaris truly possess oral hypoglycaemic activity. 2. All three plant extracts significantly lowered the fasting blood glucose level and markedly improved glucose tolerance in Sprague-Dawley rats. 3. A maximum hypoglycaemic activity was observed at + 3 hr with O. octandra and B. vulgaris; with A. heterophyllus a maximum effect was not observed even at + 5 hr. 4. The hypoglycaemic activity of O. octandra was comparable with that of tolbutamide while that of A. heterophyllus or B. vulgaris was better than that of tolbutamide. 5. The magnitude of the hypoglycaemic effects varied with the dosage used and the time of storage (except with A. heterophyllus, whose activity did not change with storage even up to 3 days).

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ER -

Hypoglycaemic activity of some medicinal plants in Sri-Lanka

Abstract

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