Hypoplasia of the cerebellar vermis in neurogenetic syndromes

G. Bradley Schaefer, James N. Thompson, John B. Bodensteiner, James M. McConnell, William J. Kimberling, Charles T. Gay, William D. Dutton, David C. Hutchings, Stanton B. Gray

    Research output: Contribution to journalArticlepeer-review

    57 Scopus citations


    There are conflicting reports on the relationship between cerebellar vermal lobule hypoplasia and autism. Using quantitative magnetic resonance image analysis, we measured the cerebellar vermis in 125 normal individuals with a broad age range and 102 patients with a variety of neurogenetic abnormalities. We conclude that hypoplasia of cerebellar vermal lobules VI and VII is a nonspecific finding that even occurs in several conditions without autistic behavior. This suggests that it is not a specific neuroanatomical marker for autism, nor is cerebellar dysgenesis likely to be solely responsible for clinical autistic behaviors.

    Original languageEnglish (US)
    Pages (from-to)382-385
    Number of pages4
    JournalAnnals of Neurology
    Issue number3
    StatePublished - 1996

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology


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