Hypoplasia of the cerebellar vermis in neurogenetic syndromes

G. Bradley Schaefer, James N. Thompson, John B. Bodensteiner, James M. McConnell, William J. Kimberling, Charles T. Gay, William D. Dutton, David C. Hutchings, Stanton B. Gray

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


There are conflicting reports on the relationship between cerebellar vermal lobule hypoplasia and autism. Using quantitative magnetic resonance image analysis, we measured the cerebellar vermis in 125 normal individuals with a broad age range and 102 patients with a variety of neurogenetic abnormalities. We conclude that hypoplasia of cerebellar vermal lobules VI and VII is a nonspecific finding that even occurs in several conditions without autistic behavior. This suggests that it is not a specific neuroanatomical marker for autism, nor is cerebellar dysgenesis likely to be solely responsible for clinical autistic behaviors.

Original languageEnglish (US)
Pages (from-to)382-385
Number of pages4
JournalAnnals of Neurology
Issue number3
StatePublished - 1996

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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