Hypothalamic hamartoma: A report of 2 cases

Rodney S. Markin; Lyal G. Leibrock; Carol A. Husemanc; Rodney D. McComb

doi:10.1159/000120296

Hypothalamic hamartoma: A report of 2 cases

Rodney S. Markin, Lyal G. Leibrock, Carol A. Husemanc, Rodney D. McComb

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

Two patients with hypothalamic hamartoma presented with isosexual precocious puberty. LHRH challenge showed a pubertal LH response in both cases. Serum FSH responses to LHRH were pubertal in case 1, but prepubertal for case 2. Computed tomography revealed isodense noncontrast-enhancing retrosellar mass lesions in both cases. The tumors were composed of mature neurons and neuroglial tissue. Electron microscopy of the lesions failed to demonstrate dense core (neurosecretory) granules in either case. Subtotal removal of the harmartomas resulted in decreased LH responsiveness to LHRH in both cases. Serum FSH responsiveness to LHRH was not significantly suppressed postoperatively in case 1, and FSH responsiveness to LHRH in case 2 showed exaggerated levels, more typical of very young prepubertal girls. Postoperative magnetic resonance imaging (MRI) scans of both patients are also presented.

Original language	English (US)
Pages (from-to)	19-26
Number of pages	8
Journal	Pediatric Neurosurgery
Volume	13
Issue number	1
DOIs	https://doi.org/10.1159/000120296
State	Published - 1987

Keywords

Hamartoma
Hypothalamus
Puberty, precocious

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Surgery
Clinical Neurology

Access to Document

10.1159/000120296

Fingerprint Dive into the research topics of 'Hypothalamic hamartoma: A report of 2 cases'. Together they form a unique fingerprint.

Cite this

Markin, R. S., Leibrock, L. G., Husemanc, C. A., & McComb, R. D. (1987). Hypothalamic hamartoma: A report of 2 cases. Pediatric Neurosurgery, 13(1), 19-26. https://doi.org/10.1159/000120296

@article{d775c5ae660d4d07aeafd9913f3a0776,

title = "Hypothalamic hamartoma: A report of 2 cases",

abstract = "Two patients with hypothalamic hamartoma presented with isosexual precocious puberty. LHRH challenge showed a pubertal LH response in both cases. Serum FSH responses to LHRH were pubertal in case 1, but prepubertal for case 2. Computed tomography revealed isodense noncontrast-enhancing retrosellar mass lesions in both cases. The tumors were composed of mature neurons and neuroglial tissue. Electron microscopy of the lesions failed to demonstrate dense core (neurosecretory) granules in either case. Subtotal removal of the harmartomas resulted in decreased LH responsiveness to LHRH in both cases. Serum FSH responsiveness to LHRH was not significantly suppressed postoperatively in case 1, and FSH responsiveness to LHRH in case 2 showed exaggerated levels, more typical of very young prepubertal girls. Postoperative magnetic resonance imaging (MRI) scans of both patients are also presented.",

keywords = "Hamartoma, Hypothalamus, Puberty, precocious",

author = "Markin, {Rodney S.} and Leibrock, {Lyal G.} and Husemanc, {Carol A.} and McComb, {Rodney D.}",

year = "1987",

doi = "10.1159/000120296",

language = "English (US)",

volume = "13",

pages = "19--26",

journal = "Pediatric Neurosurgery",

issn = "1016-2291",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Hypothalamic hamartoma

T2 - A report of 2 cases

AU - Markin, Rodney S.

AU - Leibrock, Lyal G.

AU - Husemanc, Carol A.

AU - McComb, Rodney D.

PY - 1987

Y1 - 1987

N2 - Two patients with hypothalamic hamartoma presented with isosexual precocious puberty. LHRH challenge showed a pubertal LH response in both cases. Serum FSH responses to LHRH were pubertal in case 1, but prepubertal for case 2. Computed tomography revealed isodense noncontrast-enhancing retrosellar mass lesions in both cases. The tumors were composed of mature neurons and neuroglial tissue. Electron microscopy of the lesions failed to demonstrate dense core (neurosecretory) granules in either case. Subtotal removal of the harmartomas resulted in decreased LH responsiveness to LHRH in both cases. Serum FSH responsiveness to LHRH was not significantly suppressed postoperatively in case 1, and FSH responsiveness to LHRH in case 2 showed exaggerated levels, more typical of very young prepubertal girls. Postoperative magnetic resonance imaging (MRI) scans of both patients are also presented.

AB - Two patients with hypothalamic hamartoma presented with isosexual precocious puberty. LHRH challenge showed a pubertal LH response in both cases. Serum FSH responses to LHRH were pubertal in case 1, but prepubertal for case 2. Computed tomography revealed isodense noncontrast-enhancing retrosellar mass lesions in both cases. The tumors were composed of mature neurons and neuroglial tissue. Electron microscopy of the lesions failed to demonstrate dense core (neurosecretory) granules in either case. Subtotal removal of the harmartomas resulted in decreased LH responsiveness to LHRH in both cases. Serum FSH responsiveness to LHRH was not significantly suppressed postoperatively in case 1, and FSH responsiveness to LHRH in case 2 showed exaggerated levels, more typical of very young prepubertal girls. Postoperative magnetic resonance imaging (MRI) scans of both patients are also presented.

KW - Hamartoma

KW - Hypothalamus

KW - Puberty, precocious

UR - http://www.scopus.com/inward/record.url?scp=0023481538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023481538&partnerID=8YFLogxK

U2 - 10.1159/000120296

DO - 10.1159/000120296

M3 - Article

C2 - 3120166

AN - SCOPUS:0023481538

VL - 13

SP - 19

EP - 26

JO - Pediatric Neurosurgery

JF - Pediatric Neurosurgery

SN - 1016-2291

IS - 1

ER -