12 Scopus citations

Abstract

Importance of the field: Follicular lymphoma (FL) is a subgroup of B-cell Non-Hodgkin's lymphomas (NHL) that account for 15 30% of all lymphomas. I-131 tositumomab is a radiommunoconjugate of 131I and the anti-CD20 monoclonal antibody tositumomab. It is one of two available radioimmunoconjugates for the treatment of recurrent, refractory, or transformed FL. Areas covered in this review: This review describes the clinical pharmacology of I-131 tositumomab, dosing and administration guidelines, and the key clinical trials providing evidence of its efficacy and safety in patients with FL, transformed, or other aggressive B-NHL, in combination with chemotherapy, or its incorporation in transplant conditioning regimens. This review also covers safety and regulatory concerns regarding the use of I-131 tositumomab. What the reader will gain: This review critically appraises the clinical trials behind approval of I-131 tositumomab as a second-line agent for FL and also outlines the data supporting its use in the upfront setting. Take home message: I-131 tositumomab is a safe and effective option for patients with recurrent, refractory, or transformed FL and carries promise in the upfront treatment of FL, aggressive B-NHL, and as a transplant conditioning regimen.

Original languageEnglish (US)
Pages (from-to)1271-1278
Number of pages8
JournalExpert Opinion on Biological Therapy
Volume10
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • Follicular lymphoma
  • I-131 tositumomab
  • Lymphoma
  • Monoclonal antibody
  • Radioimmunoconjugates
  • Radioimmunotherapy
  • Transplant

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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