Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm

Lili Guo; Deanna J. Volle; Robert E. Lewis

doi:10.1016/j.fob.2014.04.004

Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm

Lili Guo, Deanna J. Volle, Robert E. Lewis

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk-1 (Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2^-/- mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T-KSR2). Further analysis demonstrates T-KSR2 is specific to mouse testes and mature sperm cells. The detection of T-KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility.

Original language	English (US)
Pages (from-to)	420-425
Number of pages	6
Journal	FEBS Open Bio
Volume	4
DOIs	https://doi.org/10.1016/j.fob.2014.04.004
State	Published - 2014

Keywords

KSR2
Scaffold
Sperm

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.fob.2014.04.004

Cite this

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title = "Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm",

abstract = "The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk-1 (Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2-/- mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T-KSR2). Further analysis demonstrates T-KSR2 is specific to mouse testes and mature sperm cells. The detection of T-KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility.",

keywords = "KSR2, Scaffold, Sperm",

author = "Lili Guo and Volle, {Deanna J.} and Lewis, {Robert E.}",

note = "Funding Information: We thank Dr. Mario Fernandez for his help in preparing the manuscript and Dr. MaLinda Henry for help in sperm collection. This research was supported by the NIH grant R01 CA090400 and U.S. Army award W081XWH-10-1-0139.",

year = "2014",

doi = "10.1016/j.fob.2014.04.004",

language = "English (US)",

volume = "4",

pages = "420--425",

journal = "FEBS Open Bio",

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publisher = "Elsevier BV",

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T1 - Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm

AU - Guo, Lili

AU - Volle, Deanna J.

AU - Lewis, Robert E.

N1 - Funding Information: We thank Dr. Mario Fernandez for his help in preparing the manuscript and Dr. MaLinda Henry for help in sperm collection. This research was supported by the NIH grant R01 CA090400 and U.S. Army award W081XWH-10-1-0139.

PY - 2014

Y1 - 2014

N2 - The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk-1 (Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2-/- mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T-KSR2). Further analysis demonstrates T-KSR2 is specific to mouse testes and mature sperm cells. The detection of T-KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility.

AB - The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk-1 (Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2-/- mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T-KSR2). Further analysis demonstrates T-KSR2 is specific to mouse testes and mature sperm cells. The detection of T-KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility.

KW - KSR2

KW - Scaffold

KW - Sperm

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DO - 10.1016/j.fob.2014.04.004

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JO - FEBS Open Bio

JF - FEBS Open Bio

ER -

Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm

Abstract

Keywords

ASJC Scopus subject areas

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