TY - JOUR
T1 - Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of Lysobacter antibioticus
AU - Sang, Moli
AU - Wang, Haoxin
AU - Shen, Yuemao
AU - Rodrigues De Almeida, Nathalia
AU - Conda-Sheridan, Martin
AU - Li, Shanren
AU - Li, Yaoyao
AU - Du, Liangcheng
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/8/16
Y1 - 2019/8/16
N2 - Lysobacter are ubiquitous in the environment but remain largely underexplored, although the bacteria are considered "peptide specialists". Here, we identified a new cyclic lipodepsipeptide, WBP-29479A1 (1), through genome mining of L. antibioticus ATCC 29479. 1 is biosynthesized by a large NRPS gene cluster, and its structure, including the six nonproteinogenic residues and 3-hydroxy fatty acid, was determined by extensive spectroscopic analyses and chemical derivatization. 1 exhibits potent anti-MRSA activity in a menaquinone-dependent manner.
AB - Lysobacter are ubiquitous in the environment but remain largely underexplored, although the bacteria are considered "peptide specialists". Here, we identified a new cyclic lipodepsipeptide, WBP-29479A1 (1), through genome mining of L. antibioticus ATCC 29479. 1 is biosynthesized by a large NRPS gene cluster, and its structure, including the six nonproteinogenic residues and 3-hydroxy fatty acid, was determined by extensive spectroscopic analyses and chemical derivatization. 1 exhibits potent anti-MRSA activity in a menaquinone-dependent manner.
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U2 - 10.1021/acs.orglett.9b02333
DO - 10.1021/acs.orglett.9b02333
M3 - Article
C2 - 31386380
AN - SCOPUS:85070914793
SN - 1523-7060
VL - 21
SP - 6432
EP - 6436
JO - Organic Letters
JF - Organic Letters
IS - 16
ER -