Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of Lysobacter antibioticus

Moli Sang, Haoxin Wang, Yuemao Shen, Nathalia Rodrigues De Almeida, Martin Conda-Sheridan, Shanren Li, Yaoyao Li, Liangcheng Du

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Lysobacter are ubiquitous in the environment but remain largely underexplored, although the bacteria are considered "peptide specialists". Here, we identified a new cyclic lipodepsipeptide, WBP-29479A1 (1), through genome mining of L. antibioticus ATCC 29479. 1 is biosynthesized by a large NRPS gene cluster, and its structure, including the six nonproteinogenic residues and 3-hydroxy fatty acid, was determined by extensive spectroscopic analyses and chemical derivatization. 1 exhibits potent anti-MRSA activity in a menaquinone-dependent manner.

Original languageEnglish (US)
Pages (from-to)6432-6436
Number of pages5
JournalOrganic Letters
Volume21
Issue number16
DOIs
StatePublished - Aug 16 2019

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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