TY - JOUR
T1 - Identification of an Anti-MRSA Cyclic Lipodepsipeptide, WBP-29479A1, by Genome Mining of Lysobacter antibioticus
AU - Sang, Moli
AU - Wang, Haoxin
AU - Shen, Yuemao
AU - Rodrigues De Almeida, Nathalia
AU - Conda-Sheridan, Martin
AU - Li, Shanren
AU - Li, Yaoyao
AU - Du, Liangcheng
N1 - Funding Information:
This work was supported in part by the NSFC (Nos. 81773598 and 81573311), the Young Scholars Program of Shandong University (No. 2016WLJH31), the Fundamental Research Funds of Shandong University (No. 2018JC004), Taishan Scholars Program of Shandong Province, and University of Nebraska’s Collaboration Initiative grant program. We thank the Community for Open Antimicrobial Drug Discovery for evaluation of antimicrobial and other biological activities.
Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/8/16
Y1 - 2019/8/16
N2 - Lysobacter are ubiquitous in the environment but remain largely underexplored, although the bacteria are considered "peptide specialists". Here, we identified a new cyclic lipodepsipeptide, WBP-29479A1 (1), through genome mining of L. antibioticus ATCC 29479. 1 is biosynthesized by a large NRPS gene cluster, and its structure, including the six nonproteinogenic residues and 3-hydroxy fatty acid, was determined by extensive spectroscopic analyses and chemical derivatization. 1 exhibits potent anti-MRSA activity in a menaquinone-dependent manner.
AB - Lysobacter are ubiquitous in the environment but remain largely underexplored, although the bacteria are considered "peptide specialists". Here, we identified a new cyclic lipodepsipeptide, WBP-29479A1 (1), through genome mining of L. antibioticus ATCC 29479. 1 is biosynthesized by a large NRPS gene cluster, and its structure, including the six nonproteinogenic residues and 3-hydroxy fatty acid, was determined by extensive spectroscopic analyses and chemical derivatization. 1 exhibits potent anti-MRSA activity in a menaquinone-dependent manner.
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U2 - 10.1021/acs.orglett.9b02333
DO - 10.1021/acs.orglett.9b02333
M3 - Article
C2 - 31386380
AN - SCOPUS:85070914793
SN - 1523-7060
VL - 21
SP - 6432
EP - 6436
JO - Organic Letters
JF - Organic Letters
IS - 16
ER -