Identification of genes important in predicting the overall survival in patients with follicular lymphoma

Li Xiao, Kai Fu, Javeed Iqbal, Wing C. Chan, Simon Sherman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work, we propose to use the class comparison methods of median absolute deviation (MAD), Significance Analysis of Microarray (SAM) and Principal Component Analysis (PCA) for selecting important genes related to survival in lymphoma gene expression profiles. MAD is applied for selecting the genes whose expression values have maximal variation across the samples. SAM identifies genes with statistically significant changes in expression by assimilating a set of gene-specific t tests. Principal Component Analysis (PCA) is a linear projection method that defines a new dimensional space (samples by principal components) that captures the maximum information present in the initial data set (samples by genes). It is demonstrated that the expression measurement of the selected genes has a strong relation to the survival time. The selected genes can be used as features in building the class predication model.

Original languageEnglish (US)
Title of host publicationProceedings of the 2005 International Conference on Data Mining, DMIN'05
Pages181-186
Number of pages6
StatePublished - 2005
Event2005 International Conference on Data Mining, DMIN'05 - Las Vegas, NV, United States
Duration: Jun 20 2005Jun 23 2005

Publication series

NameProceedings of the 2005 International Conference on Data Mining, DMIN'05

Conference

Conference2005 International Conference on Data Mining, DMIN'05
CountryUnited States
CityLas Vegas, NV
Period6/20/056/23/05

Keywords

  • Follicular lymphoma
  • Gene expression
  • Principal component analysis
  • Significance analysis

ASJC Scopus subject areas

  • Computer Science Applications
  • Software

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  • Cite this

    Xiao, L., Fu, K., Iqbal, J., Chan, W. C., & Sherman, S. (2005). Identification of genes important in predicting the overall survival in patients with follicular lymphoma. In Proceedings of the 2005 International Conference on Data Mining, DMIN'05 (pp. 181-186). (Proceedings of the 2005 International Conference on Data Mining, DMIN'05).