Identification of herpes simplex virus type 1 proteins encoded within the first 1.5 kb of the latency-associated transcript

Gail Henderson, Tareq Jaber, Dale Carpenter, Steven L. Wechsler, Clinton Jones

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Expression of the first 1.5 kb of the latency-associated transcript (LAT) that is encoded by herpes simplex virus type 1 (HSV-1) is sufficient for wild-type (wt) levels of reactivation from latency in small animal models. Peptide-specific immunoglobulin G (IgG) was generated against open reading frames (ORFs) that are located within the first 1.5 kb of LAT coding sequences. Cells stably transfected with LAT or trigeminal ganglionic neurons of mice infected with a LAT expressing virus appeared to express the L2 or L8 ORF. Only L2 ORF expression was readily detected in trigeminal ganglionic neurons of latently infected mice.

Original languageEnglish (US)
Pages (from-to)439-448
Number of pages10
JournalJournal of neurovirology
Volume15
Issue number5-6
DOIs
StatePublished - Dec 12 2009

Keywords

  • Herpes simplex virus type 1
  • Latency-associated transcript

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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