Identification of trace element-containing proteins in genomic databases

Vadim N. Gladyshev, Gregory V. Kryukov, Dmitri E. Fomenko, Dolph L. Hatfield

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Development of bioinformatics tools provided researchers with the ability to identify full sets of trace element-containing proteins in organisms for which complete genomic sequences are available. Recently, independent bioinformatics methods were used to identify all, or almost all, genes encoding selenocysteine-containing proteins in human, mouse, and Drosophila genomes, characterizing entire selenoproteomes in these organisms. It also should be possible to search for entire sets of other trace element-associated proteins, such as metal-containing proteins, although methods for their identification are still in development.

Original languageEnglish (US)
Pages (from-to)579-596
Number of pages18
JournalAnnual Review of Nutrition
Volume24
DOIs
StatePublished - 2004

Keywords

  • Bioinformatics
  • Metal-containing proteins
  • Selenium
  • Selenoprotein
  • Selenoproteome

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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