IgG-4 Related Disease: An Introduction

Orwah M. Al-Khalili, Alan R. Erickson

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


IgG4-related disease (IgG-RD) describes a group of fibroinflammatory diseases that affect a variety of tissues resulting in tumor-like effect and/or organ dysfunction. Clinical presentation varies according to the tissue(s) involved, and diagnosis relies on tissue findings of dense infiltration of IgG4-positive plasma cells and a characteristic storiform fibrosis. Treatment is mainly with glucocorticoids, while multiple immunosuppressive medications can be used as adjuvant agents. Rituximab has showed promising results, but further studies are needed.

Original languageEnglish (US)
Pages (from-to)253-256
Number of pages4
JournalMissouri medicine
Issue number3
StatePublished - May 1 2018

ASJC Scopus subject areas

  • Medicine(all)


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