IL-18 is required for self-reactive T cell expansion in NOD mice

Annette M. Marleau, Nora E. Sarvetnick

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

IL-18 has a well-established role in pro-inflammatory responses in the islets in type 1 diabetes. Here, we identify a distinctive role for IL-18 in expanding pathogenic T cells in the periphery of NOD mice. Well in advance of disease onset, the periphery of IL-18-deficient mice exhibits reduced T cell turnover, an increased prevalence of naïve and quiescent T cells, emergence of fewer effector T cells, and disease protection. Islet-reactive T cells fail to become activated in the lymphoid organs of mice lacking IL-18 and their rapid expansion is inhibited. IL-18 secretion by antigen presenting cells increases with advancing disease and is required for expression of its receptor on T cells. Our results demonstrate that induction of the IL-18 receptor reflects a critical stage of autoreactive T cell activation and expansion on the pathway toward effector T cell differentiation. This study therefore assigns a novel role to IL-18 for expanding the pool of islet-destructive T cells during pre-diabetes. This report highlights a new basic mechanism in type 1 diabetes pathogenesis and suggests that targeting the IL-18 pathway should be explored as a potential treatment strategy.

Original languageEnglish (US)
Pages (from-to)263-277
Number of pages15
JournalJournal of Autoimmunity
Volume36
Issue number3-4
DOIs
StatePublished - May 2011

Keywords

  • IL-18
  • T cells
  • Type 1 diabetes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'IL-18 is required for self-reactive T cell expansion in NOD mice'. Together they form a unique fingerprint.

  • Cite this