IL-23 in infections, inflammation, autoimmunity and cancer: Possible role in HIV-1 and AIDS

Govardhana Rao Yannam; Tanuja Gutti; Larisa Y. Poluektova

doi:10.1007/s11481-011-9315-2

IL-23 in infections, inflammation, autoimmunity and cancer: Possible role in HIV-1 and AIDS

Govardhana Rao Yannam, Tanuja Gutti, Larisa Y. Poluektova

Pharmacology & Experimental Neuroscience (PEN)

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

The growing family of interleukin (IL)-12-like cytokines produced by activated macrophages and dendritic cells became the important players in the control of infections, development of inflammation, autoimmunity and cancer. However, the role of one of them-heterodimer IL-23, which consists of IL12p40 and the unique p19 subunit in HIV-1 infection pathogenesis and progression to AIDS, represent special interest. We overviewed findings of IL-23 involvement in control of peripheral bacterial pathogens and opportunistic infection, central nervous system (CNS) viral infections and autoimmune disorders, and tumorogenesis, which potentially could be applicable to HIV-1 and AIDS.

Original language	English (US)
Pages (from-to)	95-112
Number of pages	18
Journal	Journal of Neuroimmune Pharmacology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1007/s11481-011-9315-2
State	Published - Mar 2012

Keywords

Autoimmune disorders
Bacterial infection
Central nervous system
HIV-1
IL-23
Interleukin-17

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Immunology and Allergy
Immunology
Pharmacology

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title = "IL-23 in infections, inflammation, autoimmunity and cancer: Possible role in HIV-1 and AIDS",

abstract = "The growing family of interleukin (IL)-12-like cytokines produced by activated macrophages and dendritic cells became the important players in the control of infections, development of inflammation, autoimmunity and cancer. However, the role of one of them-heterodimer IL-23, which consists of IL12p40 and the unique p19 subunit in HIV-1 infection pathogenesis and progression to AIDS, represent special interest. We overviewed findings of IL-23 involvement in control of peripheral bacterial pathogens and opportunistic infection, central nervous system (CNS) viral infections and autoimmune disorders, and tumorogenesis, which potentially could be applicable to HIV-1 and AIDS.",

keywords = "Autoimmune disorders, Bacterial infection, Central nervous system, HIV-1, IL-23, Interleukin-17",

author = "Yannam, {Govardhana Rao} and Tanuja Gutti and Poluektova, {Larisa Y.}",

note = "Funding Information: Acknowledgments This work was supported by National Institutes of Health Grants 5 P20 RR021937-02, 5 P01 NS043985-07. We acknowledge Deepa Roy, Jaclyn Knibbe, Edward Makarov, Santhi Gorantla for assistance.",

year = "2012",

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doi = "10.1007/s11481-011-9315-2",

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AU - Gutti, Tanuja

AU - Poluektova, Larisa Y.

N1 - Funding Information: Acknowledgments This work was supported by National Institutes of Health Grants 5 P20 RR021937-02, 5 P01 NS043985-07. We acknowledge Deepa Roy, Jaclyn Knibbe, Edward Makarov, Santhi Gorantla for assistance.

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