TY - JOUR
T1 - IL-23 in infections, inflammation, autoimmunity and cancer
T2 - Possible role in HIV-1 and AIDS
AU - Yannam, Govardhana Rao
AU - Gutti, Tanuja
AU - Poluektova, Larisa Y.
N1 - Funding Information:
Acknowledgments This work was supported by National Institutes of Health Grants 5 P20 RR021937-02, 5 P01 NS043985-07. We acknowledge Deepa Roy, Jaclyn Knibbe, Edward Makarov, Santhi Gorantla for assistance.
PY - 2012/3
Y1 - 2012/3
N2 - The growing family of interleukin (IL)-12-like cytokines produced by activated macrophages and dendritic cells became the important players in the control of infections, development of inflammation, autoimmunity and cancer. However, the role of one of them-heterodimer IL-23, which consists of IL12p40 and the unique p19 subunit in HIV-1 infection pathogenesis and progression to AIDS, represent special interest. We overviewed findings of IL-23 involvement in control of peripheral bacterial pathogens and opportunistic infection, central nervous system (CNS) viral infections and autoimmune disorders, and tumorogenesis, which potentially could be applicable to HIV-1 and AIDS.
AB - The growing family of interleukin (IL)-12-like cytokines produced by activated macrophages and dendritic cells became the important players in the control of infections, development of inflammation, autoimmunity and cancer. However, the role of one of them-heterodimer IL-23, which consists of IL12p40 and the unique p19 subunit in HIV-1 infection pathogenesis and progression to AIDS, represent special interest. We overviewed findings of IL-23 involvement in control of peripheral bacterial pathogens and opportunistic infection, central nervous system (CNS) viral infections and autoimmune disorders, and tumorogenesis, which potentially could be applicable to HIV-1 and AIDS.
KW - Autoimmune disorders
KW - Bacterial infection
KW - Central nervous system
KW - HIV-1
KW - IL-23
KW - Interleukin-17
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U2 - 10.1007/s11481-011-9315-2
DO - 10.1007/s11481-011-9315-2
M3 - Review article
C2 - 21947740
AN - SCOPUS:84860703085
VL - 7
SP - 95
EP - 112
JO - Journal of NeuroImmune Pharmacology
JF - Journal of NeuroImmune Pharmacology
SN - 1557-1890
IS - 1
ER -