Image background removal in comprehensive two-dimensional gas chromatography

Stephen E. Reichenbach, Mingtian Ni, Dongmin Zhang, Edward B. Ledford

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


This paper describes a new technique for removing the background level from digital images produced in comprehensive two-dimensional gas chromatography (GC×GC). Background removal is an important first step in the larger problem of quantitative analysis. The approach estimates the background level across the chromatographic image based on structural and statistical properties of GC×GC data. Then, the background level is subtracted from the image, producing a chromatogram in which the peaks rise above a near-zero mean background. After the background level is removed, further analysis is required to determine the quantitative relationship between the peaks and chemicals in the sample. The algorithm is demonstrated experimentally to be effective at determining and removing the background level from GC×GC images. The algorithm has several parametric controls and is incorporated into an interactive program with graphical interface for rapid and accurate detection of GC×GC peaks.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalJournal of Chromatography A
Issue number1-2
StatePublished - Jan 24 2003
Externally publishedYes


  • Gas chromatography, comprehensive two-dimensional
  • Image background removal

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry


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