Image-guided 31P magnetic resonance spectroscopy of normal and transplanted human kidneys

Michael D. Boska, Dieter J. Meyerhoff, Donald B. Twieg, Gregory S. Karczmar, Gerald B. Matson, Michael W. Weiner

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Image-guided 31-phosphorus magnetic resonance spectroscopy (MRS) was used to obtain spatially localized 31P spectra of good quality from healthy normal human kidneys and from well-functioning renal allografts. A surface coil of 14 cm diameter was used for acquiring phosphorus signals solely from a volume-of-interest located within the kidney. To determine the effects of kidney transplantation on renal metabolism, patients with well functioning allografts were studied. Little or no phosphocreatine in all spectra verifies the absence of muscle contamination, and is consistent with proper volume localization. The intensity ratio of phosphomonoesters (PME) to adenosine triphosphate (ATP) resonances in transplanted kidneys (PME/ATP = 1.1 ± 0.4) was slightly elevated (P = 0.2) compared to that of healthy normal kidneys (PME/ATP = 0.8 ± 0.3). The inorganic phosphate (Pi) to ATP ratio was similar in the two groups (Pi/ATP = 1.1 ± 0.1 in transplanted kidneys vs. 1.2 ± 0.6 in normal kidneys). Acid/base status, as evidenced from the chemical shift of Pi, was the same in both normal controls and transplanted kidneys. Despite the practical problems produced by organ depth, respiratory movement, and tissue heterogeneity, these results demonstrate that image-guided 31P MR spectra can reliably be obtained from human kidneys.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalKidney International
Issue number2
StatePublished - Aug 1990

ASJC Scopus subject areas

  • Nephrology


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