Image-guided tumor surgery: The emerging role of nanotechnology

Nicholas E. Wojtynek, Aaron M. Mohs

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Surgical resection is a mainstay treatment for solid tumors. Yet, methods to distinguish malignant from healthy tissue are primarily limited to tactile and visual cues as well as the surgeon's experience. As a result, there is a possibility that a positive surgical margin (PSM) or the presence of residual tumor left behind after resection may occur. It is well-documented that PSMs can negatively impact treatment outcomes and survival, as well as pose an economic burden. Therefore, surgical tumor imaging techniques have emerged as a promising method to decrease PSM rates. Nanoparticles (NPs) have unique characteristics to serve as optical contrast agents during image-guided surgery (IGS). Recently, there has been tremendous growth in the volume and types of NPs used for IGS, including clinical trials. Herein, we describe the most recent contributions of nanotechnology for surgical tumor identification. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery Diagnostic Tools > in vivo Nanodiagnostics and Imaging.

Original languageEnglish (US)
Article numbere1624
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Issue number4
StatePublished - Jul 1 2020


  • fluorescence-guided surgery
  • image-guided surgery
  • imaging
  • nanoparticle
  • optical
  • surgical oncology

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering


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