Imaging DNA molecules chemically bound to a mica surface (Invited Paper)

Stuart M. Lindsay; Y. L. Lyubchenko; A. A. Gall; L. S. Shlyakhtenko; R. E. Harrington

Imaging DNA molecules chemically bound to a mica surface (Invited Paper)

Stuart M. Lindsay, Y. L. Lyubchenko, A. A. Gall, L. S. Shlyakhtenko, R. E. Harrington

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We describe a procedure for imaging DNA molecules using atomic force microscopy (AFM). Double-stranded DNA binds to a mica surface modified by treatment with 3- aminopropyltriethoxysilane to yield AFM images that are stable under repeated scanning. We used this procedure to obtain high quality images of unstained linear DNA molecules and circular DNA molecules. The resolution was limited to tens of nanometers by the profile of the AFM tips.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Publisher	Publ by Int Soc for Optical Engineering
Pages	84-90
Number of pages	7
ISBN (Print)	0819407852
State	Published - 1992
Externally published	Yes
Event	Scanning Probe Microscopies - Los Angeles, CA, USA Duration: Jan 20 1992 → Jan 22 1992

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	1639
ISSN (Print)	0277-786X

Other

Other	Scanning Probe Microscopies
City	Los Angeles, CA, USA
Period	1/20/92 → 1/22/92

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Cite this

Lindsay, S. M., Lyubchenko, Y. L., Gall, A. A., Shlyakhtenko, L. S., & Harrington, R. E. (1992). Imaging DNA molecules chemically bound to a mica surface (Invited Paper). In Proceedings of SPIE - The International Society for Optical Engineering (pp. 84-90). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1639). Publ by Int Soc for Optical Engineering.

Imaging DNA molecules chemically bound to a mica surface (Invited Paper). / Lindsay, Stuart M.; Lyubchenko, Y. L.; Gall, A. A. et al.
Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering, 1992. p. 84-90 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1639).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Lindsay, SM, Lyubchenko, YL, Gall, AA, Shlyakhtenko, LS & Harrington, RE 1992, Imaging DNA molecules chemically bound to a mica surface (Invited Paper). in Proceedings of SPIE - The International Society for Optical Engineering. Proceedings of SPIE - The International Society for Optical Engineering, vol. 1639, Publ by Int Soc for Optical Engineering, pp. 84-90, Scanning Probe Microscopies, Los Angeles, CA, USA, 1/20/92.

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abstract = "We describe a procedure for imaging DNA molecules using atomic force microscopy (AFM). Double-stranded DNA binds to a mica surface modified by treatment with 3- aminopropyltriethoxysilane to yield AFM images that are stable under repeated scanning. We used this procedure to obtain high quality images of unstained linear DNA molecules and circular DNA molecules. The resolution was limited to tens of nanometers by the profile of the AFM tips.",

author = "Lindsay, {Stuart M.} and Lyubchenko, {Y. L.} and Gall, {A. A.} and Shlyakhtenko, {L. S.} and Harrington, {R. E.}",

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AU - Harrington, R. E.

PY - 1992

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AB - We describe a procedure for imaging DNA molecules using atomic force microscopy (AFM). Double-stranded DNA binds to a mica surface modified by treatment with 3- aminopropyltriethoxysilane to yield AFM images that are stable under repeated scanning. We used this procedure to obtain high quality images of unstained linear DNA molecules and circular DNA molecules. The resolution was limited to tens of nanometers by the profile of the AFM tips.

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M3 - Conference contribution

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BT - Proceedings of SPIE - The International Society for Optical Engineering

PB - Publ by Int Soc for Optical Engineering

T2 - Scanning Probe Microscopies

Y2 - 20 January 1992 through 22 January 1992

ER -

Imaging DNA molecules chemically bound to a mica surface (Invited Paper)

Abstract

Publication series

Other

ASJC Scopus subject areas

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