Imbalanced estrogen metabolism in the brain: Possible relevance to the etiology of Parkinson's disease

Nilesh W. Gaikwad; Daniel Murman; Cheryl L. Beseler; Muhammad Zahid; Eleanor G. Rogan; Ercole L. Cavalieri

doi:10.3109/1354750X.2011.588725

Imbalanced estrogen metabolism in the brain: Possible relevance to the etiology of Parkinson's disease

Nilesh W. Gaikwad, Daniel Murman, Cheryl L. Beseler, Muhammad Zahid, Eleanor G. Rogan, Ercole L. Cavalieri

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Damage to DNA by dopamine quinone and/or catechol estrogen quinones may play a significant role in the initiation of Parkinson's disease (PD). Depurinating estrogenDNA adducts are shed from cells and excreted in urine. The aim of this study was to discover whether higher levels of estrogenDNA adducts are associated with PD. Forty estrogen metabolites, conjugates, and DNA adducts were analyzed in urine samples from 20 PD cases and 40 matched controls by using ultra performance liquid chromatography/tandem mass spectrometry. The levels of adducts in cases versus controls (P < 0.005) suggest that unbalanced estrogen metabolism could play a causal role in the initiation of PD.

Original language	English (US)
Pages (from-to)	434-444
Number of pages	11
Journal	Biomarkers
Volume	16
Issue number	5
DOIs	https://doi.org/10.3109/1354750X.2011.588725
State	Published - Aug 2011

Keywords

Catechol estrogen quinones
Depurinating estrogenDNA adducts
UPLC-MS/MS
Urinary biomarkers

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2011.588725

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title = "Imbalanced estrogen metabolism in the brain: Possible relevance to the etiology of Parkinson's disease",

abstract = "Damage to DNA by dopamine quinone and/or catechol estrogen quinones may play a significant role in the initiation of Parkinson's disease (PD). Depurinating estrogenDNA adducts are shed from cells and excreted in urine. The aim of this study was to discover whether higher levels of estrogenDNA adducts are associated with PD. Forty estrogen metabolites, conjugates, and DNA adducts were analyzed in urine samples from 20 PD cases and 40 matched controls by using ultra performance liquid chromatography/tandem mass spectrometry. The levels of adducts in cases versus controls (P < 0.005) suggest that unbalanced estrogen metabolism could play a causal role in the initiation of PD.",

keywords = "Catechol estrogen quinones, Depurinating estrogenDNA adducts, UPLC-MS/MS, Urinary biomarkers",

author = "Gaikwad, {Nilesh W.} and Daniel Murman and Beseler, {Cheryl L.} and Muhammad Zahid and Rogan, {Eleanor G.} and Cavalieri, {Ercole L.}",

note = "Funding Information: This research was supported by Prevention LLC. Core support at the Eppley Institute was provided by grant P30 36727 from the National Cancer Institute. The authors report no declarations of interest.",

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T2 - Possible relevance to the etiology of Parkinson's disease

AU - Gaikwad, Nilesh W.

AU - Murman, Daniel

AU - Beseler, Cheryl L.

AU - Zahid, Muhammad

AU - Rogan, Eleanor G.

AU - Cavalieri, Ercole L.

N1 - Funding Information: This research was supported by Prevention LLC. Core support at the Eppley Institute was provided by grant P30 36727 from the National Cancer Institute. The authors report no declarations of interest.

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N2 - Damage to DNA by dopamine quinone and/or catechol estrogen quinones may play a significant role in the initiation of Parkinson's disease (PD). Depurinating estrogenDNA adducts are shed from cells and excreted in urine. The aim of this study was to discover whether higher levels of estrogenDNA adducts are associated with PD. Forty estrogen metabolites, conjugates, and DNA adducts were analyzed in urine samples from 20 PD cases and 40 matched controls by using ultra performance liquid chromatography/tandem mass spectrometry. The levels of adducts in cases versus controls (P < 0.005) suggest that unbalanced estrogen metabolism could play a causal role in the initiation of PD.

AB - Damage to DNA by dopamine quinone and/or catechol estrogen quinones may play a significant role in the initiation of Parkinson's disease (PD). Depurinating estrogenDNA adducts are shed from cells and excreted in urine. The aim of this study was to discover whether higher levels of estrogenDNA adducts are associated with PD. Forty estrogen metabolites, conjugates, and DNA adducts were analyzed in urine samples from 20 PD cases and 40 matched controls by using ultra performance liquid chromatography/tandem mass spectrometry. The levels of adducts in cases versus controls (P < 0.005) suggest that unbalanced estrogen metabolism could play a causal role in the initiation of PD.

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Imbalanced estrogen metabolism in the brain: Possible relevance to the etiology of Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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