Immune function and infectious complications in children with jejunoileal atresia

Sittichoke Prachuapthunyachart, Shaheed Merani, Madeline Cloonan, Alan N. Langnas, Ruben E. Quiros-Tejeira, Hanh D. Vo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objective: Little is known about differences in immune function among children with multiple intestinal atresia (MIA) and those with isolated intestinal atresia (IA), and how such differences may manifest as infectious complications and patient outcomes. This study aimed to investigate the immune function and its impact on patient outcomes in IA and MIA children. Methods: A single-center retrospective cohort study included children aged 0–19 years with intestinal atresia who were referred to a multidisciplinary intestinal rehabilitation program from 1/2000 to 12/2016. Data were collected for patient characteristics, surgical history, immunologic work-up, and infection-related hospitalizations. Groups of IA and MIA children were compared using chi-square test or Fisher's exact test for categorical variables and using Mann–Whitney test for continuous variables, as appropriate. Results: Twenty-seven children (18 IA, 9 MIA) were included. More than half of the patients had low CD counts for age in IA and MIA groups: CD3 58.3% vs. 66.7% (p = 1.0), CD4 50.0% vs. 66.7% (p = 0.7), CD8 67.7% vs. 88.9% (p = 0.3), respectively. Six out of 12 IA children and 3 out of 8 MIA children had hypogammaglobulinemia (p = 0.7). Three out of 10 IA patients and 3 out of 5 MIA children had frequent bacteremia (≥ 5/year). Eight children (6 IA and 2 MIA) underwent intestinal and/or liver transplant; MIA children had a worse posttransplant outcome. Conclusions: IA children may have an immunodeficiency and associated infectious complications requiring hospitalization. We suggest performing immunologic evaluation not only in MIA but also in IA children presenting to an intestinal rehabilitation program to identify immunodeficiency. Early immunodeficiency screening may help initiate appropriate intervention and improve patient outcomes. Level of evidence: Level III.

Original languageEnglish (US)
Pages (from-to)454-458
Number of pages5
JournalJournal of pediatric surgery
Issue number3
StatePublished - Mar 2021


  • Children
  • Immunodeficiency
  • Intestinal atresia
  • Jejunoileal atresia
  • Multiple intestinal atresia

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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