Immune monitoring and biomarkers to predict chronic allograft dysfunction

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Late failure of a kidney transplant continues to be a major problem after transplantation, in spite of more potent immunosuppressive strategies and the focus of clinical management shifting toward prolonging long-term graft survival. It is now recognized that graft failure occurs because of two major complications: death with a functioning graft and intrinsic allograft failure. Recent studies of late kidney graft loss have indicated a complexity of findings, including etiologies that are both immune and non-immune. These studies suggest that late graft failure is not an inevitable fact and that further investigation into the etiology of transplant graft failure may lead to a new understanding of the biology that will provide novel therapeutic strategies and biomarkers. In this review, we will focus on late allograft failure due to intrinsic injury to the transplant. The role of immune monitoring will be discussed in the context of monitoring for ongoing injury or for identifying late injury. A variety of methodologies have been used, including genomics, proteomics, and metabolomics, not only for monitoring allograft injury but also for identifying markers of graft failure that are more sensitive than serum creatinine. The available studies, as they relate to late or chronic graft injury, will also be reviewed.

Original languageEnglish (US)
Pages (from-to)S59-S65
JournalKidney International
Issue numberSUPPL. 119
StatePublished - Dec 2010
Externally publishedYes


  • ELISpot
  • biomarker
  • biopsy
  • monitoring
  • proteomics
  • transplantation

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Immune monitoring and biomarkers to predict chronic allograft dysfunction'. Together they form a unique fingerprint.

Cite this