Immunization strategies for Parkinson's disease

Duy Ha, David K. Stone, R. Lee Mosley, Howard E. Gendelman

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Currently, no curative treatments or treatments that interdict disease progression are available. Over the past decade, immunization strategies were developed in our laboratories to combat disease progression. These strategies were developed in laboratory and animal models of human disease. Induction of humoral immune responses can be elicited against misfolded protein aggregates. Robust cellmediated immunity against nitrated misfolded protein(s) accelerates disease progression through effector T cell responses that facilitate neuronal death. We propose that shifting the balance between effector and regulatory T cell activity can attenuate neurotoxic inflammatory events. We now summarize our works that support immune regulation in PD with the singular goal of restoring homeostatic glial responses. New methods to optimize immunization schemes and measure their clinical efficacy are discussed.

Original languageEnglish (US)
Pages (from-to)S218-S221
JournalParkinsonism and Related Disorders
Issue numberSUPPL. 1
StatePublished - Jan 2012


  • Effector T cells
  • Immunity
  • Immunization
  • Microglia
  • Neuroprotection
  • Regulatory T cells

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology


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