Immunologic memory 5 years after meningococcal A/C conjugate vaccination in infancy

Jenny M. MacLennan, Stephen Obaro, Jonathan Deeks, Derrick Lake, Cheryl Elie, George Carlone, E. Richard Moxon, Brian Greenwood

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Infant vaccination with meningococcal conjugates may provide long-term protection against disease. Antibody levels and immunologic memory were assessed in 5-year-old Gambian children who received meningococcal A/C conjugate vaccination (MenA/C) in infancy. At 2 years, they were randomized to receive a booster of MenA/C (conjugate group), meningococcal A/C polysaccharide (MPS group), or inactivated polio vaccine (PV group). All groups were revaccinated with 10 μg MPS at 5 years of age, as were 39 previously unvaccinated age-matched control subjects. Before revaccination, titers were higher in the conjugate and MPS groups than in control subjects (P<.001); titers for the IPV group were similar to those for control subjects. Ten days after revaccination, the conjugate and IPV groups had similar serogroup C serum bactericidal antibody titers (3421 vs. 2790, respectively). These levels were significantly higher than those in the MPS (426) and control (485) groups (P< .001). Thus, immunologic memory was sustained for ≥5 years; however, MPS challenge at 2 years interfered with a subsequent memory response.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalJournal of Infectious Diseases
Volume183
Issue number1
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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