Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease

Katherine E. Olson, Howard E. Gendelman

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


While immune control is associated with nigrostriatal neuroprotection for Parkinson's disease, direct cause and effect relationships have not yet been realized, and modulating the immune system for therapeutic gain has been openly debated. Here, we review how innate and adaptive immunity affect disease pathobiology, and how each could be harnessed for treatment. The overarching idea is to employ immunopharmacologics as neuroprotective strategies for disease. The aim of the current work is to review disease-modifying treatments that are currently being developed as neuroprotective strategies for PD in experimental animal models and for human disease translation. The long-term goal of this research is to effectively harness the immune system to slow or prevent PD pathobiology.

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalCurrent Opinion in Pharmacology
StatePublished - Feb 1 2016

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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