Immunomodulatory and therapeutic properties of alkyl lysophospholipids in mice

James E. Talmadge, Mark Schneider, Barbara Lenz, Hamblin Phillips, Cedric Long

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

This paper describes the immunomodulatory and therapeutic properties of the alkyl lysophospholipids [ALP; 1-O-octadecyl-2-O-rac-glycero-3-phosphocholine (ET-18-OCH3)]. ALP was able to activate macrophages both in vitro and in vivo as well as to act as an immunoadjuvant for syngeneic tumor vaccines. However, ALP appeared to be transferred, at least in part, to the macrophage membrane, and some of the tumoricidal macrophage-activating properties seem to be associated with the direct cytotoxic effect of membrane-released ALP. ALP also had some therapeutic activity for experimental and spontaneous metastases, requiring administration three but not two times weekly at near-toxic doses; this suggests that at least some of its therapeutic activity is due to direct cytotoxicity.

Original languageEnglish (US)
Pages (from-to)871-877
Number of pages7
JournalLipids
Volume22
Issue number11
DOIs
StatePublished - Nov 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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