Immunophenotypic and genotypic characterization of lymphomatoid papulosis

Jeff D. Parks, Mark S. Synovec, Aneal S. Masih, Suzanne W. Braddock, Hirokazu Nakamine, Warren G. Sanger, Douglas S. Harrington, Dennis D. Weisenburger

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Abstract

Background: Lymphomatoid papulosis (LyP) is a chronic dermatosis that histologically resembles malignant lymphoma. Thus far, only a few cases of LyP have been characterized in detail with regard to immunophenotype, genotype, and karyotype. Objective: Our purpose was to study seven patients with LyP and compare the results to those reported in the literature. Methods: Skin biopsy specimens were analyzed by frozen section immunohistochemical and molecular biologic techniques. Cytogenetic analysis was also performed in three cases. Results: The atypical lymphoid cells consisted of activated helper T cells; four of the seven patients had lesions with a detectable clonal T-cell population. A peripheral T-cell lymphoma developed in one patient before the emergence of a genotypically different LyP T-cell clone. Cytogenetic studies were abnormal in one case of LyP and normal in another, whereas the karyotype of the lymphoma was abnormal. Conclusion: LyP is a preneoplastic proliferation of activated helper T cells, which is often clonal and may regress and expand with the development of new LyP clones or lymphoma.

Original languageEnglish (US)
Pages (from-to)968-975
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume26
Issue number6
DOIs
Publication statusPublished - Jan 1 1992

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ASJC Scopus subject areas

  • Dermatology

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Parks, J. D., Synovec, M. S., Masih, A. S., Braddock, S. W., Nakamine, H., Sanger, W. G., ... Weisenburger, D. D. (1992). Immunophenotypic and genotypic characterization of lymphomatoid papulosis. Journal of the American Academy of Dermatology, 26(6), 968-975. https://doi.org/10.1016/0190-9622(92)70143-4