Immunosuppressive effects of ganciclovir on in vitro lymphocyte responses

Raleigh A. Bowden; Jon Digel; Elizabeth C. Reed; Joel D. Meyers

doi:10.1093/infdis/156.6.899

Immunosuppressive effects of ganciclovir on in vitro lymphocyte responses

Raleigh A. Bowden, Jon Digel, Elizabeth C. Reed, Joel D. Meyers

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

We evaluated the effect of ganciclovir on in vitro immune responses by lymphocytes from healthy individuals. At clinically relevant concentrations, ganciclovir inhibited proliferation responses to cytomegalovirus antigen and to phytohemagglutinin by b50% but had no effect on production of interleukin-2 or γ interferon to these stimuli or on cytotoxicity against cytomegalovirus-infected, HLA-mismatched target cells. These results showed that ganciclovir inhibits lymphocyte functions for which lymphocyte proliferation is required but does not affect lymphocyte responses that do not require DNA synthesis. Studies of the effect on the immune responses in patients receiving ganciclovir will be needed to determine in vivo correlates of these findings.

Original language	English (US)
Pages (from-to)	899-903
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	156
Issue number	6
DOIs	https://doi.org/10.1093/infdis/156.6.899
State	Published - Dec 1987
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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@article{d45e0b37bebb465c8ae37afe7536eaaf,

title = "Immunosuppressive effects of ganciclovir on in vitro lymphocyte responses",

abstract = "We evaluated the effect of ganciclovir on in vitro immune responses by lymphocytes from healthy individuals. At clinically relevant concentrations, ganciclovir inhibited proliferation responses to cytomegalovirus antigen and to phytohemagglutinin by b50% but had no effect on production of interleukin-2 or γ interferon to these stimuli or on cytotoxicity against cytomegalovirus-infected, HLA-mismatched target cells. These results showed that ganciclovir inhibits lymphocyte functions for which lymphocyte proliferation is required but does not affect lymphocyte responses that do not require DNA synthesis. Studies of the effect on the immune responses in patients receiving ganciclovir will be needed to determine in vivo correlates of these findings.",

author = "Bowden, {Raleigh A.} and Jon Digel and Reed, {Elizabeth C.} and Meyers, {Joel D.}",

note = "Funding Information: This work was supported by grants CA-18029, CA-15704, and CA-2696§from the National Cancer Institute; by grant HL-36444 from tne'NatiohaIHeart, Lung, and Blood Institute; and by grants from the Poncin Foundation and the Burroughs Wellcome Company.",

year = "1987",

month = dec,

doi = "10.1093/infdis/156.6.899",

language = "English (US)",

volume = "156",

pages = "899--903",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

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AU - Bowden, Raleigh A.

AU - Digel, Jon

AU - Reed, Elizabeth C.

AU - Meyers, Joel D.

N1 - Funding Information: This work was supported by grants CA-18029, CA-15704, and CA-2696§from the National Cancer Institute; by grant HL-36444 from tne'NatiohaIHeart, Lung, and Blood Institute; and by grants from the Poncin Foundation and the Burroughs Wellcome Company.

PY - 1987/12

Y1 - 1987/12

N2 - We evaluated the effect of ganciclovir on in vitro immune responses by lymphocytes from healthy individuals. At clinically relevant concentrations, ganciclovir inhibited proliferation responses to cytomegalovirus antigen and to phytohemagglutinin by b50% but had no effect on production of interleukin-2 or γ interferon to these stimuli or on cytotoxicity against cytomegalovirus-infected, HLA-mismatched target cells. These results showed that ganciclovir inhibits lymphocyte functions for which lymphocyte proliferation is required but does not affect lymphocyte responses that do not require DNA synthesis. Studies of the effect on the immune responses in patients receiving ganciclovir will be needed to determine in vivo correlates of these findings.

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