Immunosuppressive therapy for autoimmune inner ear disease

Maria C. Buniel, Katie Geelan-Hansen, Peter C. Weber, Vincent K. Tuohy

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Autoimmune inner ear disease (AIED) is a rare disease that is diagnosed after clinical suspicion and response to corticosteroids. AIED manifests as progressive, bilateral, although often asynchronous, sensorineural hearing loss and can be associated with vestibular symptoms. Since its description as a defined disease entity in 1979, the initial mainstay of treatment remains high-dose corticosteroids. Several animal models have been developed to assist in determining efficacy of immunosuppression in AIED, and several clinical studies have also investigated the role of both steroid and steroid-sparing treatments. Here we discuss the basic science and clinical research surrounding the history of immunosuppressive therapy in AIED.

Original languageEnglish (US)
Pages (from-to)425-434
Number of pages10
JournalImmunotherapy
Volume1
Issue number3
DOIs
StatePublished - Dec 24 2009

Keywords

  • Autoimmunity
  • Corticosteroid
  • Hearing loss
  • Immunomodulation
  • Immunosuppression

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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