Immunosuppressive therapy for severe aplastic anemia

Phyllis I. Warkentin, Norma K.C. Ramsay, William Krivit, Peter Felix Coccia, Mark E. Nesbit, Richard Condie, John H. Kersey

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Evidence for an immunologic etiology for severe aplastic anemia and the role of immunosuppres-sion as therapy for aplastic anemia are discussed. In vitro marrow culture studies of granulocytic and erythroid colonies demonstrating immunologically mediated stem cell destruction are described. Case reports from the literature of autologous recovery after attempted bone marrow transplantation and the use of antilymphocyte globulins and cyclophosphamide for the treatment of aplastic anemia are reviewed. The response of four of nine severely aplastic children at the University of Minnesota to antithymocyte globulin and a second response to antithymocyte globulin seen in two patients after recurrence of severe aplasia are reported. Prospects for future studies of the immunologic aspects of aplastic anemia and for potential therapies are considered.

Original languageEnglish (US)
Pages (from-to)327-339
Number of pages13
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume2
Issue number4
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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    Warkentin, P. I., Ramsay, N. K. C., Krivit, W., Coccia, P. F., Nesbit, M. E., Condie, R., & Kersey, J. H. (1980). Immunosuppressive therapy for severe aplastic anemia. American Journal of Pediatric Hematology/Oncology, 2(4), 327-339.