Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose

James E. Talmadge; Joanne Adams; Hamblin Phillips; Margaret Collins; Barbara Lenz; Mark Schneider; Michael Chirigos

Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose

James E. Talmadge, Joanne Adams, Hamblin Phillips, Margaret Collins, Barbara Lenz, Mark Schneider, Michael Chirigos

Research output: Contribution to journal › Article › peer-review

Abstract

The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose [poly(l,C)-LC] eradicated established experimental and spontaneous pulmonary metastases. Optimal immunotherapy was schedule dependent, requiring three to five injections of poly(l,C)-LC per week for a minimum of 4 weeks; in addition, therapeutic efficiency was partially dosage independent. Immunotherapy by poly(l,C)-LC was found to be limited by tumor burden, although when combined with chemotherapy as a de-bulking regimen it resulted in increased survival with protocols in which poly(l,C)-LC alone was insufficient. These data suggest that the systemic administration of Poly(l,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.

Original language	English (US)
Pages (from-to)	1066-1072
Number of pages	7
Journal	Cancer Research
Volume	45
Issue number	3
State	Published - Mar 1 1985
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose. / Talmadge, James E.; Adams, Joanne; Phillips, Hamblin; Collins, Margaret; Lenz, Barbara; Schneider, Mark; Chirigos, Michael.

In: Cancer Research, Vol. 45, No. 3, 01.03.1985, p. 1066-1072.

Research output: Contribution to journal › Article › peer-review

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abstract = "The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose [poly(l,C)-LC] eradicated established experimental and spontaneous pulmonary metastases. Optimal immunotherapy was schedule dependent, requiring three to five injections of poly(l,C)-LC per week for a minimum of 4 weeks; in addition, therapeutic efficiency was partially dosage independent. Immunotherapy by poly(l,C)-LC was found to be limited by tumor burden, although when combined with chemotherapy as a de-bulking regimen it resulted in increased survival with protocols in which poly(l,C)-LC alone was insufficient. These data suggest that the systemic administration of Poly(l,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.",

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Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose

Abstract

ASJC Scopus subject areas

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