Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose

James E. Talmadge; Joanne Adams; Hamblin Phillips; Margaret Collins; Barbara Lenz; Mark Schneider; Michael Chirigos

Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose

James E. Talmadge, Joanne Adams, Hamblin Phillips, Margaret Collins, Barbara Lenz, Mark Schneider, Michael Chirigos

Research output: Contribution to journal › Article › peer-review

Abstract

The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose [poly(l,C)-LC] eradicated established experimental and spontaneous pulmonary metastases. Optimal immunotherapy was schedule dependent, requiring three to five injections of poly(l,C)-LC per week for a minimum of 4 weeks; in addition, therapeutic efficiency was partially dosage independent. Immunotherapy by poly(l,C)-LC was found to be limited by tumor burden, although when combined with chemotherapy as a de-bulking regimen it resulted in increased survival with protocols in which poly(l,C)-LC alone was insufficient. These data suggest that the systemic administration of Poly(l,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.

Original language	English (US)
Pages (from-to)	1066-1072
Number of pages	7
Journal	Cancer Research
Volume	45
Issue number	3
State	Published - Mar 1 1985
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

@article{66664909f35c44648efbad2162b04bb4,

title = "Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose",

abstract = "The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose [poly(l,C)-LC] eradicated established experimental and spontaneous pulmonary metastases. Optimal immunotherapy was schedule dependent, requiring three to five injections of poly(l,C)-LC per week for a minimum of 4 weeks; in addition, therapeutic efficiency was partially dosage independent. Immunotherapy by poly(l,C)-LC was found to be limited by tumor burden, although when combined with chemotherapy as a de-bulking regimen it resulted in increased survival with protocols in which poly(l,C)-LC alone was insufficient. These data suggest that the systemic administration of Poly(l,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.",

author = "Talmadge, {James E.} and Joanne Adams and Hamblin Phillips and Margaret Collins and Barbara Lenz and Mark Schneider and Michael Chirigos",

year = "1985",

month = mar,

day = "1",

language = "English (US)",

volume = "45",

pages = "1066--1072",

journal = "Cancer Research",

issn = "0008-5472",

number = "3",

}

TY - JOUR

T1 - Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose

AU - Talmadge, James E.

AU - Adams, Joanne

AU - Phillips, Hamblin

AU - Collins, Margaret

AU - Lenz, Barbara

AU - Schneider, Mark

AU - Chirigos, Michael

PY - 1985/3/1

Y1 - 1985/3/1

N2 - The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose [poly(l,C)-LC] eradicated established experimental and spontaneous pulmonary metastases. Optimal immunotherapy was schedule dependent, requiring three to five injections of poly(l,C)-LC per week for a minimum of 4 weeks; in addition, therapeutic efficiency was partially dosage independent. Immunotherapy by poly(l,C)-LC was found to be limited by tumor burden, although when combined with chemotherapy as a de-bulking regimen it resulted in increased survival with protocols in which poly(l,C)-LC alone was insufficient. These data suggest that the systemic administration of Poly(l,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.

AB - The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose [poly(l,C)-LC] eradicated established experimental and spontaneous pulmonary metastases. Optimal immunotherapy was schedule dependent, requiring three to five injections of poly(l,C)-LC per week for a minimum of 4 weeks; in addition, therapeutic efficiency was partially dosage independent. Immunotherapy by poly(l,C)-LC was found to be limited by tumor burden, although when combined with chemotherapy as a de-bulking regimen it resulted in increased survival with protocols in which poly(l,C)-LC alone was insufficient. These data suggest that the systemic administration of Poly(l,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.

UR - http://www.scopus.com/inward/record.url?scp=0021950864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021950864&partnerID=8YFLogxK

M3 - Article

C2 - 3971361

AN - SCOPUS:0021950864

VL - 45

SP - 1066

EP - 1072

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 3

ER -

Immunotherapeutic Potential in Murine Tumor Models of Polyinosinic-Polycytidylic Acid and Poly-L-lysine Solubilized by Carboxymethylcellulose

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this