Abstract
Aim: To investigate the association of stereotactic radiation therapy (SRT) or whole-brain radiation therapy (WBRT) plus immunotherapy with the overall survival (OS) of cancer patients with brain metastases (BMs) regardless of the primary cancer. Patients & methods: Patients diagnosed with BMs were identified from the National Cancer Database. Results: A total of 34,286 patients were included. SRT plus immunotherapy was associated with improved OS compared with SRT without immunotherapy (hazard ratio: 0.774; 95% CI: 0.687-0.872; p < 0.001), and WBRT plus immunotherapy was associated with improved OS compared with WBRT without immunotherapy (hazard ratio: 0.724; 95% CI; 0.673-0.779; p < 0.001). Conclusion: SRT plus immunotherapy was associated with improved OS compared with SRT. WBRT plus immunotherapy was associated with improved OS compared with WBRT in cancer patients who had BMs at the time of primary cancer diagnosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 163-174 |
| Number of pages | 12 |
| Journal | Immunotherapy |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 1 2023 |
Keywords
- National Cancer Database
- brain RT
- brain metastases
- chemotherapy
- immunotherapy
- overall survival
- stereotactic body radiation therapy
- whole-brain radiation therapy
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology